Coronary artery ectasia: Current concepts and interventions

Ahmed S. Aboeata, Siva P. Sontineni, Venkata (Mahesh) Alla, Dennis J. Esterbrooks

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Coronary artery ectasia (CAE) is a wellrecognized angiographic finding, characterized by abnormal dilatation of the coronary arteries. We reviewed the current concepts of the condition including etiology, pathogenesis, flow alterations, clinical implications, prognosis and treatment. CAE is often viewed as a variant of obstructive coronary atherosclerosis. Exaggerated positive vascular remodeling due to inflammation, and chronic overstimulation of the endothelium by nitric oxide are potential causative mechanisms. The condition is associated with cardiovascular risk factors such as smoking and hypertension, while it appears to be inversely associated with age and diabetes mellitus. Patients with CAE typically present with angina, and are at risk for myocardial infarctions and sudden cardiac death due to slow flow, coronary vasospasm, dissection, and/or intracoronary thrombosis. CAE may be a diffuse disease associated with dilatation in other parts of the vasculature. As the incidence of this not so benign condition is expected to rise, the optimal treatment options remain undefined. Medical therapy with anticoagulants, nitrates and calcium channel blockers has been proposed and seems rational; however prospective studies with proof of efficacy are needed.

Original languageEnglish
Pages (from-to)300-310
Number of pages11
JournalFrontiers in Bioscience - Elite
Volume4 E
Issue number1
StatePublished - Jan 1 2012

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Pathologic Dilatations
Coronary Vessels
Dissection
Calcium Channel Blockers
Medical problems
Anticoagulants
Nitrates
Nitric Oxide
Dilatation
Coronary Vasospasm
Sudden Cardiac Death
Endothelium
Coronary Artery Disease
Diabetes Mellitus
Thrombosis
Therapeutics
Smoking
Myocardial Infarction
Prospective Studies
Hypertension

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Coronary artery ectasia : Current concepts and interventions. / Aboeata, Ahmed S.; Sontineni, Siva P.; Alla, Venkata (Mahesh); Esterbrooks, Dennis J.

In: Frontiers in Bioscience - Elite, Vol. 4 E, No. 1, 01.01.2012, p. 300-310.

Research output: Contribution to journalArticle

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