Correcting calcium nutritional deficiency prevents spine fractures in elderly women

Robert R. Recker, Sharilyn Hinders, K. Michael Davies, Robert P. Heaney, Mary Ruth Stegman, Joan M. Lappe, Donald B. Kimmel

Research output: Contribution to journalArticle

294 Citations (Scopus)

Abstract

We tested the spine antifracture and bone sparing efficacy of 1.2 g/day of oral calcium as carbonate in two groups of elderly women, one with prevalent fractures (PF, n = 94) on entry and the other without (NPF, n = 103). It was a prospective randomized, double-blind, placebo-controlled trial in mostly rural communities in women over age 60 who were living independently and were consuming <1 g/day of calcium. We obtained annual lateral spine radiographs and semiannual forearm bone density over 4.3 ± 1.1 years and determined vertebral fractures by radiographic morphometry augmented by physician assessment. In the PF group, 15 of 53 subjects on calcium had incident fractures, compared with 21 of 41 on placebo (p = 0.023, χ2). Calcium did not reduce the rate of incident fractures in the NPF group. Those with a prevalent fracture on entry and not treated with calcium were 2.8 times more likely to experience an incident fracture than all others. Change in the forearm bone mass on placebo in the PF group was -1.24 ± 2.41%/year compared with +0.31 ± 1.80%/year on calcium (p <0.001). In the NPF group, the difference was less: -0.39 ± 2.08%/year versus 0.00 ± 1.64%/year (p = 0.2). We conclude that in elderly postmenopausal women with spine fractures and selfselected calcium intakes of <1 g/day, a calcium supplement of 1.2 g/day reduces the incidence of spine fractures and halts measurable bone loss.

Original languageEnglish
Pages (from-to)1961-1966
Number of pages6
JournalJournal of Bone and Mineral Research
Volume11
Issue number12
StatePublished - Dec 1996

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Malnutrition
Spine
Calcium
Placebos
Forearm
Bone and Bones
Calcium Carbonate
Rural Population
Bone Density
Physicians
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Recker, R. R., Hinders, S., Davies, K. M., Heaney, R. P., Stegman, M. R., Lappe, J. M., & Kimmel, D. B. (1996). Correcting calcium nutritional deficiency prevents spine fractures in elderly women. Journal of Bone and Mineral Research, 11(12), 1961-1966.

Correcting calcium nutritional deficiency prevents spine fractures in elderly women. / Recker, Robert R.; Hinders, Sharilyn; Davies, K. Michael; Heaney, Robert P.; Stegman, Mary Ruth; Lappe, Joan M.; Kimmel, Donald B.

In: Journal of Bone and Mineral Research, Vol. 11, No. 12, 12.1996, p. 1961-1966.

Research output: Contribution to journalArticle

Recker, RR, Hinders, S, Davies, KM, Heaney, RP, Stegman, MR, Lappe, JM & Kimmel, DB 1996, 'Correcting calcium nutritional deficiency prevents spine fractures in elderly women', Journal of Bone and Mineral Research, vol. 11, no. 12, pp. 1961-1966.
Recker, Robert R. ; Hinders, Sharilyn ; Davies, K. Michael ; Heaney, Robert P. ; Stegman, Mary Ruth ; Lappe, Joan M. ; Kimmel, Donald B. / Correcting calcium nutritional deficiency prevents spine fractures in elderly women. In: Journal of Bone and Mineral Research. 1996 ; Vol. 11, No. 12. pp. 1961-1966.
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