Correlation of inhibitory effects of polymers on indomethacin precipitation in solution and amorphous solid crystallization based on molecular interaction

Harsh Chauhan, Anuj Kuldipkumar, Timothy Barder, Ales Medek, Chong Hui Gu, Eman Atef

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Purpose: To correlate the polymer's degree of precipitation inhibition of indomethacin in solution to the amorphous stabilization in solid state. Methods: Precipitation of indomethacin (IMC) in presence of polymers was continuously monitored by a UV spectrophotometer. Precipitates were characterized by PXRD, IR and SEM. Solid dispersions with different polymer to drug ratios were prepared using solvent evaporation. Crystallization of the solid dispersion was monitored using PXRD. Modulated differential scanning calorimetry (MDSC), IR, Raman and solid state NMR were used to explore the possible interactions between IMC and polymers. Results: PVP K90, HPMC and Eudragit E100 showed precipitation inhibitory effects in solution whereas Eudragit L100, Eudragit S100 and PEG 8000 showed no effect on IMC precipitation. The rank order of precipitation inhibitory effect on IMC was found to be PVP K90 > Eudragit E100 > HPMC. In the solid state, polymers showing precipitation inhibitory effect also exhibited amorphous stabilization of IMC with the same rank order of effectiveness. IR, Raman and solid state NMR studies showed that rank order of crystallization inhibition correlates with strength of molecular interaction between IMC and polymers. Conclusions: Correlation is observed in the polymers ability to inhibit precipitation in solution and amorphous stabilization in the solid state for IMC and can be explained by the strength of drug polymer interactions.

Original languageEnglish
Pages (from-to)500-515
Number of pages16
JournalPharmaceutical Research
Volume31
Issue number2
DOIs
StatePublished - Feb 2014

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Molecular interactions
Crystallization
Indomethacin
Polymers
Stabilization
Nuclear magnetic resonance
Ultraviolet spectrophotometers
Differential Scanning Calorimetry
Dispersions
Drug Interactions
Pharmaceutical Preparations
Precipitates
Differential scanning calorimetry
Evaporation
Scanning electron microscopy

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science
  • Organic Chemistry
  • Molecular Medicine
  • Pharmacology (medical)
  • Biotechnology
  • Pharmacology

Cite this

Correlation of inhibitory effects of polymers on indomethacin precipitation in solution and amorphous solid crystallization based on molecular interaction. / Chauhan, Harsh; Kuldipkumar, Anuj; Barder, Timothy; Medek, Ales; Gu, Chong Hui; Atef, Eman.

In: Pharmaceutical Research, Vol. 31, No. 2, 02.2014, p. 500-515.

Research output: Contribution to journalArticle

Chauhan, Harsh ; Kuldipkumar, Anuj ; Barder, Timothy ; Medek, Ales ; Gu, Chong Hui ; Atef, Eman. / Correlation of inhibitory effects of polymers on indomethacin precipitation in solution and amorphous solid crystallization based on molecular interaction. In: Pharmaceutical Research. 2014 ; Vol. 31, No. 2. pp. 500-515.
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