COX-2 expression in pseudomyxoma peritonei

Zoran Gatalica, Brian Loggie

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

COX-2 expression was studied using an immunohistochemical method in 75 patients with pseudomyxoma peritonei (PMP). Twenty-five patients presented with disseminated peritoneal adenomucinosis (DPAM) and 50 with peritoneal mucinous carcinomatosis (PMCA). COX-2 was expressed in neoplastic mucinous epithelium of 30 cases (40%): 20 in PMCA (40%), 10 in DPAM (40%). Weak COX-2 expression was also noted in four of five patients with appendiceal mucinous neoplasms without peritoneal dissemination. In addition, COX-2 was detected in stromal, endothelial, inflammatory cells and reactive mesothelium. This preliminary information indicates a potential for the use of COX-2 inhibitors in patients with PMP.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalCancer Letters
Volume244
Issue number1
DOIs
StatePublished - Nov 28 2006

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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