Coxsackievirus B3 murine myocarditis

A pathologic spectrum of myocarditis in genetically defined inbred strains

A. Herskowitz, L. J. Wolfgram, N. R. Rose, Kirk Beisel

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Group B coxsackieviruses are the most frequent causative agents in human viral myocarditis. Susceptibility to viral infections varies widely among individuals. In the mouse, coxsackievirus B3 also causes myocarditis. The differential susceptibility of different inbred strains of mice to coxsackie B3-induced myocarditis also appears to be under genetic control. This study details the histopathology of coxsackie B3 myocarditis in six different inbred strains of mice for the first 45 days after coxsackie B3 infection. These strains differ either in the haplotypes of their major histocompatibility complex or in their background genome. During the first 7 days after coxsackie B3 infection, there are dramatic differences among strains with respect to prevalence and severity of myocarditis. Focal zones of myocyte necrosis involving polymorphonuclear leukocytes as well as contraction band injury appear to be the early manifestations of direct viral injury. Four of the six strains, though, continue to show myocardial inflammation after day 9. This late phase myocarditis is characterized by the emergence of mononuclear cells within healing foci of myocyte necrosis as well as a distinctive diffuse interstitial pattern of myocarditis. The strains that develop this late ongoing myocardial inflammation frequently produce heart-specific autoantibodies. Thus 1) the pathologic features of murine coxsackie B3 myocarditis change over the course of the illness, and 2) genetic susceptibility to both early and late phase myocarditis differs markedly among various mouse strains.

Original languageEnglish
Pages (from-to)1311-1319
Number of pages9
JournalJournal of the American College of Cardiology
Volume9
Issue number6
StatePublished - 1987
Externally publishedYes

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Enterovirus
Myocarditis
Inbred Strains Mice
Muscle Cells
Necrosis
Inflammation
Human Enterovirus B
Wounds and Injuries
Virus Diseases
Genetic Predisposition to Disease
Infection
Major Histocompatibility Complex
Autoantibodies
Haplotypes
Neutrophils
Genome

All Science Journal Classification (ASJC) codes

  • Nursing(all)

Cite this

Coxsackievirus B3 murine myocarditis : A pathologic spectrum of myocarditis in genetically defined inbred strains. / Herskowitz, A.; Wolfgram, L. J.; Rose, N. R.; Beisel, Kirk.

In: Journal of the American College of Cardiology, Vol. 9, No. 6, 1987, p. 1311-1319.

Research output: Contribution to journalArticle

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