Coxsackievirus B3 murine myocarditis: A pathologic spectrum of myocarditis in genetically defined inbred strains

Ahvie Herskowitz, Luanne J. Wolfgram, Noel R. Rose, Kirk W. Beisel

Research output: Contribution to journalArticlepeer-review

91 Scopus citations


Group B coxsackieviruses are the most frequent causative agents in human viral myocarditis. Susceptibility to viral infections varies widely among individuals. In the mouse, coxsackievirus B3 also causes myocarditis. The differential susceptibility of different inbred strains of mice to coxsackie B3-induced myocarditis also appears to be under genetic control. This study details the histopathology of coxsackie B3 myocarditis in six different inbred strains of mice for the first 45 days after coxsackie B3 infection. These strains differ either in the haplotypes of their major histocompatibility complex or in their background genome. During the first 7 days after coxsackie B3 infection, there are dramatic differences among strains with respect to prevalence and severity of myocarditis. Focal zones of myocyte necrosis involving polymorphonuclear leukocytes as well as contraction band injury appear to be the early manifestations of direct viral injury. Four of the six strains, though, continue to show myocardial inflammation after day 9. This late phase myocarditis is characterized by the emergence of mononuclear cells within healing foci of myocyte necrosis as well as a distinctive diffuse interstitial pattern of myocarditis. The strains that develop this late ongoing myocardial inflammation frequently produce heart-specific autoantibodies. Thus 1) the pathologic features of murine coxsackie B3 myocarditis change over the course of the illness, and 2) genetic susceptibility to both early and late phase myocarditis differs markedly among various mouse strains.

Original languageEnglish (US)
Pages (from-to)1311-1319
Number of pages9
JournalJournal of the American College of Cardiology
Issue number6
StatePublished - 1987
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine


Dive into the research topics of 'Coxsackievirus B3 murine myocarditis: A pathologic spectrum of myocarditis in genetically defined inbred strains'. Together they form a unique fingerprint.

Cite this