Credneramides A and B

Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.

Karla L. Malloy, Takashi L. Suyama, Niclas Engene, Hosana Debonsi, Zhengyu Cao, Teatulohi Matainaho, Carmenza Spadafora, Thomas F. Murray, William H. Gerwick

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC 50 4.0 μM; 2, IC 50 3.8 μM).

Original languageEnglish
Pages (from-to)60-66
Number of pages7
JournalJournal of Natural Products
Volume75
Issue number1
DOIs
StatePublished - Jan 27 2012

Fingerprint

Vinyl Chloride
Fatty Acids
Panama
Derivatives
Papua New Guinea
Calcium Signaling
Metabolites
Biological Products
Neurons
Calcium
Acids
Trichodesmium
phenethylamine
credneramide B
credneramide A

All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Credneramides A and B : Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov. / Malloy, Karla L.; Suyama, Takashi L.; Engene, Niclas; Debonsi, Hosana; Cao, Zhengyu; Matainaho, Teatulohi; Spadafora, Carmenza; Murray, Thomas F.; Gerwick, William H.

In: Journal of Natural Products, Vol. 75, No. 1, 27.01.2012, p. 60-66.

Research output: Contribution to journalArticle

Malloy, Karla L. ; Suyama, Takashi L. ; Engene, Niclas ; Debonsi, Hosana ; Cao, Zhengyu ; Matainaho, Teatulohi ; Spadafora, Carmenza ; Murray, Thomas F. ; Gerwick, William H. / Credneramides A and B : Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov. In: Journal of Natural Products. 2012 ; Vol. 75, No. 1. pp. 60-66.
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AU - Debonsi, Hosana

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