Abstract
Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC 50 4.0 μM; 2, IC 50 3.8 μM).
| Original language | English |
|---|---|
| Pages (from-to) | 60-66 |
| Number of pages | 7 |
| Journal | Journal of Natural Products |
| Volume | 75 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 27 2012 |
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All Science Journal Classification (ASJC) codes
- Complementary and alternative medicine
- Molecular Medicine
- Organic Chemistry
- Analytical Chemistry
- Pharmaceutical Science
- Pharmacology
- Drug Discovery
Cite this
Credneramides A and B : Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov. / Malloy, Karla L.; Suyama, Takashi L.; Engene, Niclas; Debonsi, Hosana; Cao, Zhengyu; Matainaho, Teatulohi; Spadafora, Carmenza; Murray, Thomas F.; Gerwick, William H.
In: Journal of Natural Products, Vol. 75, No. 1, 27.01.2012, p. 60-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Credneramides A and B
T2 - Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.
AU - Malloy, Karla L.
AU - Suyama, Takashi L.
AU - Engene, Niclas
AU - Debonsi, Hosana
AU - Cao, Zhengyu
AU - Matainaho, Teatulohi
AU - Spadafora, Carmenza
AU - Murray, Thomas F.
AU - Gerwick, William H.
PY - 2012/1/27
Y1 - 2012/1/27
N2 - Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC 50 4.0 μM; 2, IC 50 3.8 μM).
AB - Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC 50 4.0 μM; 2, IC 50 3.8 μM).
UR - http://www.scopus.com/inward/record.url?scp=84856488112&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856488112&partnerID=8YFLogxK
U2 - 10.1021/np200611f
DO - 10.1021/np200611f
M3 - Article
VL - 75
SP - 60
EP - 66
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 1
ER -