Credneramides A and B: Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.

Karla L. Malloy, Takashi L. Suyama, Niclas Engene, Hosana Debonsi, Zhengyu Cao, Teatulohi Matainaho, Carmenza Spadafora, Thomas F. Murray, William H. Gerwick

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Abstract

Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC 50 4.0 μM; 2, IC 50 3.8 μM).

Original languageEnglish
Pages (from-to)60-66
Number of pages7
JournalJournal of Natural Products
Volume75
Issue number1
DOIs
StatePublished - Jan 27 2012

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All Science Journal Classification (ASJC) codes

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

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