Credneramides A and B: Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.

Karla L. Malloy, Takashi L. Suyama, Niclas Engene, Hosana Debonsi, Zhengyu Cao, Teatulohi Matainaho, Carmenza Spadafora, Thomas F. Murray, William H. Gerwick

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC 50 4.0 μM; 2, IC 50 3.8 μM).

Original languageEnglish (US)
Pages (from-to)60-66
Number of pages7
JournalJournal of Natural Products
Volume75
Issue number1
DOIs
StatePublished - Jan 27 2012

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Credneramides A and B: Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.'. Together they form a unique fingerprint.

  • Cite this