Credneramides A and B: Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.

Karla L. Malloy; Takashi L. Suyama; Niclas Engene; Hosana Debonsi; Zhengyu Cao; Teatulohi Matainaho; Carmenza Spadafora; Thomas F. Murray; William H. Gerwick

doi:10.1021/np200611f

Credneramides A and B: Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.

Karla L. Malloy, Takashi L. Suyama, Niclas Engene, Hosana Debonsi, Zhengyu Cao, Teatulohi Matainaho, Carmenza Spadafora, Thomas F. Murray, William H. Gerwick

Department of Pharmacology and Neuroscience

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC ₅₀ 4.0 μM; 2, IC ₅₀ 3.8 μM).

Original language	English (US)
Pages (from-to)	60-66
Number of pages	7
Journal	Journal of Natural Products
Volume	75
Issue number	1
DOIs	https://doi.org/10.1021/np200611f
State	Published - Jan 27 2012

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/np200611f

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title = "Credneramides A and B: Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.",

abstract = "Credneramides A (1) and B (2), two vinyl chloride-containing metabolites, were isolated from a Papua New Guinea collection of cf. Trichodesmium sp. nov. and expand a recently described class of vinyl chloride-containing natural products. The precursor fatty acid, credneric acid (3), was isolated from both the aqueous and organic fractions of the parent fraction as well as from another geographically and phylogenetically distinct cyanobacterial collection (Panama). Credneramides A and B inhibited spontaneous calcium oscillations in murine cerebrocortical neurons at low micromolar concentrations (1, IC 50 4.0 μM; 2, IC 50 3.8 μM).",

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AU - Malloy, Karla L.

AU - Suyama, Takashi L.

AU - Engene, Niclas

AU - Debonsi, Hosana

AU - Cao, Zhengyu

AU - Matainaho, Teatulohi

AU - Spadafora, Carmenza

AU - Murray, Thomas F.

AU - Gerwick, William H.

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Credneramides A and B: Neuromodulatory phenethylamine and isopentylamine derivatives of a vinyl chloride-containing fatty acid from cf. Trichodesmium sp. nov.

Abstract

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