Abstract
The action mechanism of cromolyn sodium and its effect on bronchial sensitivity to allergen, methacholine chloride, and histamine inhalations were studied in 17 asthmatic subjects. Cromolyn capsules or placebo was administered by an inhaler (Spinhaler) randomly on alternate days 30 minutes before aerosol challenge. Cromolyn and placebo did not differ in their effect on bronchial response to histamine or methacholine. However, the degree of decrease in forced vital capacity and forced expiratory volume in one second after allergen challenge was significantly reduced by cromolyn in 15 of 17 subjects. Immediate and delayed reactions of itching, tightness, or wheezing developed in 14 subjects after allergen challenges following placebo intake and were prevented or substantially inhibited by cromolyn.
| Original language | English |
|---|---|
| Pages (from-to) | 927-931 |
| Number of pages | 5 |
| Journal | JAMA - Journal of the American Medical Association |
| Volume | 236 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 23 1976 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
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Cromolyn Therapy in Patients With Bronchial Asthma : Effect on Inhalation Challenge With Allergen, Histamine, and Methacholine. / Ryo, Ung Yun; Kang, Bann; Townley, Robert G.
In: JAMA - Journal of the American Medical Association, Vol. 236, No. 8, 23.08.1976, p. 927-931.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cromolyn Therapy in Patients With Bronchial Asthma
T2 - Effect on Inhalation Challenge With Allergen, Histamine, and Methacholine
AU - Ryo, Ung Yun
AU - Kang, Bann
AU - Townley, Robert G.
PY - 1976/8/23
Y1 - 1976/8/23
N2 - The action mechanism of cromolyn sodium and its effect on bronchial sensitivity to allergen, methacholine chloride, and histamine inhalations were studied in 17 asthmatic subjects. Cromolyn capsules or placebo was administered by an inhaler (Spinhaler) randomly on alternate days 30 minutes before aerosol challenge. Cromolyn and placebo did not differ in their effect on bronchial response to histamine or methacholine. However, the degree of decrease in forced vital capacity and forced expiratory volume in one second after allergen challenge was significantly reduced by cromolyn in 15 of 17 subjects. Immediate and delayed reactions of itching, tightness, or wheezing developed in 14 subjects after allergen challenges following placebo intake and were prevented or substantially inhibited by cromolyn.
AB - The action mechanism of cromolyn sodium and its effect on bronchial sensitivity to allergen, methacholine chloride, and histamine inhalations were studied in 17 asthmatic subjects. Cromolyn capsules or placebo was administered by an inhaler (Spinhaler) randomly on alternate days 30 minutes before aerosol challenge. Cromolyn and placebo did not differ in their effect on bronchial response to histamine or methacholine. However, the degree of decrease in forced vital capacity and forced expiratory volume in one second after allergen challenge was significantly reduced by cromolyn in 15 of 17 subjects. Immediate and delayed reactions of itching, tightness, or wheezing developed in 14 subjects after allergen challenges following placebo intake and were prevented or substantially inhibited by cromolyn.
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U2 - 10.1001/jama.1976.03270090021019
DO - 10.1001/jama.1976.03270090021019
M3 - Article
VL - 236
SP - 927
EP - 931
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0002-9955
IS - 8
ER -