Cryosurgery of close or positive margins after hepatic resection for primary and metastatic hepatobiliary malignancies

Perry Shen, Aaron Hoffman, Russell Howerton, Brian W. Loggie

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Obtaining a one-centimeter negative margin is an important factor in preventing disease recurrence after surgery for hepatic tumors. Cryotherapy of the resected edge has been used to achieve optimal margin clearance in cases in which the alternative would be an extended high-risk liver resection. The effect of this technique on margin recurrence was examined. Between 1994 and 2001 a total of 56 patients underwent cryosurgery with or without resection for primary and metastatic hepatobiliary malignancies. A 5-cm cryotherapy lollipop probe was used to ablate surgical margins less than one centimeter in 13 of these patients. There were seven colorectal metastases, three hepatocellular carcinomas, and three gallbladder carcinomas. The median size of the colorectal and hepatocellular lesions was 3 cm (range 2-14 cm), and all gallbladder primaries were T2 tumors. All tumors except three were located centrally in the liver requiring cryoablation of margins at segments 4, 5, and 8. Most patients had one site frozen (n = 9) with a median target temperature of -190°C and a median of two freeze-thaw cycles. Final pathological analysis of the resected specimens revealed nine close (

Original languageEnglish
Pages (from-to)695-703
Number of pages9
JournalAmerican Surgeon
Volume68
Issue number8
StatePublished - 2002
Externally publishedYes

Fingerprint

Cryosurgery
Cryotherapy
Liver
Gallbladder
Neoplasms
Recurrence
Hepatocellular Carcinoma
Neoplasm Metastasis
Carcinoma
Temperature

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Cryosurgery of close or positive margins after hepatic resection for primary and metastatic hepatobiliary malignancies. / Shen, Perry; Hoffman, Aaron; Howerton, Russell; Loggie, Brian W.

In: American Surgeon, Vol. 68, No. 8, 2002, p. 695-703.

Research output: Contribution to journalArticle

@article{fd9a6c1fbd064b6195ae1a2c6f5e0932,
title = "Cryosurgery of close or positive margins after hepatic resection for primary and metastatic hepatobiliary malignancies",
abstract = "Obtaining a one-centimeter negative margin is an important factor in preventing disease recurrence after surgery for hepatic tumors. Cryotherapy of the resected edge has been used to achieve optimal margin clearance in cases in which the alternative would be an extended high-risk liver resection. The effect of this technique on margin recurrence was examined. Between 1994 and 2001 a total of 56 patients underwent cryosurgery with or without resection for primary and metastatic hepatobiliary malignancies. A 5-cm cryotherapy lollipop probe was used to ablate surgical margins less than one centimeter in 13 of these patients. There were seven colorectal metastases, three hepatocellular carcinomas, and three gallbladder carcinomas. The median size of the colorectal and hepatocellular lesions was 3 cm (range 2-14 cm), and all gallbladder primaries were T2 tumors. All tumors except three were located centrally in the liver requiring cryoablation of margins at segments 4, 5, and 8. Most patients had one site frozen (n = 9) with a median target temperature of -190°C and a median of two freeze-thaw cycles. Final pathological analysis of the resected specimens revealed nine close (",
author = "Perry Shen and Aaron Hoffman and Russell Howerton and Loggie, {Brian W.}",
year = "2002",
language = "English",
volume = "68",
pages = "695--703",
journal = "American Surgeon",
issn = "0003-1348",
publisher = "Southeastern Surgical Congress",
number = "8",

}

TY - JOUR

T1 - Cryosurgery of close or positive margins after hepatic resection for primary and metastatic hepatobiliary malignancies

AU - Shen, Perry

AU - Hoffman, Aaron

AU - Howerton, Russell

AU - Loggie, Brian W.

PY - 2002

Y1 - 2002

N2 - Obtaining a one-centimeter negative margin is an important factor in preventing disease recurrence after surgery for hepatic tumors. Cryotherapy of the resected edge has been used to achieve optimal margin clearance in cases in which the alternative would be an extended high-risk liver resection. The effect of this technique on margin recurrence was examined. Between 1994 and 2001 a total of 56 patients underwent cryosurgery with or without resection for primary and metastatic hepatobiliary malignancies. A 5-cm cryotherapy lollipop probe was used to ablate surgical margins less than one centimeter in 13 of these patients. There were seven colorectal metastases, three hepatocellular carcinomas, and three gallbladder carcinomas. The median size of the colorectal and hepatocellular lesions was 3 cm (range 2-14 cm), and all gallbladder primaries were T2 tumors. All tumors except three were located centrally in the liver requiring cryoablation of margins at segments 4, 5, and 8. Most patients had one site frozen (n = 9) with a median target temperature of -190°C and a median of two freeze-thaw cycles. Final pathological analysis of the resected specimens revealed nine close (

AB - Obtaining a one-centimeter negative margin is an important factor in preventing disease recurrence after surgery for hepatic tumors. Cryotherapy of the resected edge has been used to achieve optimal margin clearance in cases in which the alternative would be an extended high-risk liver resection. The effect of this technique on margin recurrence was examined. Between 1994 and 2001 a total of 56 patients underwent cryosurgery with or without resection for primary and metastatic hepatobiliary malignancies. A 5-cm cryotherapy lollipop probe was used to ablate surgical margins less than one centimeter in 13 of these patients. There were seven colorectal metastases, three hepatocellular carcinomas, and three gallbladder carcinomas. The median size of the colorectal and hepatocellular lesions was 3 cm (range 2-14 cm), and all gallbladder primaries were T2 tumors. All tumors except three were located centrally in the liver requiring cryoablation of margins at segments 4, 5, and 8. Most patients had one site frozen (n = 9) with a median target temperature of -190°C and a median of two freeze-thaw cycles. Final pathological analysis of the resected specimens revealed nine close (

UR - http://www.scopus.com/inward/record.url?scp=0036676954&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036676954&partnerID=8YFLogxK

M3 - Article

VL - 68

SP - 695

EP - 703

JO - American Surgeon

JF - American Surgeon

SN - 0003-1348

IS - 8

ER -