Abstract
Obtaining a one-centimeter negative margin is an important factor in preventing disease recurrence after surgery for hepatic tumors. Cryotherapy of the resected edge has been used to achieve optimal margin clearance in cases in which the alternative would be an extended high-risk liver resection. The effect of this technique on margin recurrence was examined. Between 1994 and 2001 a total of 56 patients underwent cryosurgery with or without resection for primary and metastatic hepatobiliary malignancies. A 5-cm cryotherapy lollipop probe was used to ablate surgical margins less than one centimeter in 13 of these patients. There were seven colorectal metastases, three hepatocellular carcinomas, and three gallbladder carcinomas. The median size of the colorectal and hepatocellular lesions was 3 cm (range 2-14 cm), and all gallbladder primaries were T2 tumors. All tumors except three were located centrally in the liver requiring cryoablation of margins at segments 4, 5, and 8. Most patients had one site frozen (n = 9) with a median target temperature of -190°C and a median of two freeze-thaw cycles. Final pathological analysis of the resected specimens revealed nine close (
| Original language | English |
|---|---|
| Pages (from-to) | 695-703 |
| Number of pages | 9 |
| Journal | American Surgeon |
| Volume | 68 |
| Issue number | 8 |
| State | Published - 2002 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Surgery
Cite this
Cryosurgery of close or positive margins after hepatic resection for primary and metastatic hepatobiliary malignancies. / Shen, Perry; Hoffman, Aaron; Howerton, Russell; Loggie, Brian W.
In: American Surgeon, Vol. 68, No. 8, 2002, p. 695-703.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cryosurgery of close or positive margins after hepatic resection for primary and metastatic hepatobiliary malignancies
AU - Shen, Perry
AU - Hoffman, Aaron
AU - Howerton, Russell
AU - Loggie, Brian W.
PY - 2002
Y1 - 2002
N2 - Obtaining a one-centimeter negative margin is an important factor in preventing disease recurrence after surgery for hepatic tumors. Cryotherapy of the resected edge has been used to achieve optimal margin clearance in cases in which the alternative would be an extended high-risk liver resection. The effect of this technique on margin recurrence was examined. Between 1994 and 2001 a total of 56 patients underwent cryosurgery with or without resection for primary and metastatic hepatobiliary malignancies. A 5-cm cryotherapy lollipop probe was used to ablate surgical margins less than one centimeter in 13 of these patients. There were seven colorectal metastases, three hepatocellular carcinomas, and three gallbladder carcinomas. The median size of the colorectal and hepatocellular lesions was 3 cm (range 2-14 cm), and all gallbladder primaries were T2 tumors. All tumors except three were located centrally in the liver requiring cryoablation of margins at segments 4, 5, and 8. Most patients had one site frozen (n = 9) with a median target temperature of -190°C and a median of two freeze-thaw cycles. Final pathological analysis of the resected specimens revealed nine close (
AB - Obtaining a one-centimeter negative margin is an important factor in preventing disease recurrence after surgery for hepatic tumors. Cryotherapy of the resected edge has been used to achieve optimal margin clearance in cases in which the alternative would be an extended high-risk liver resection. The effect of this technique on margin recurrence was examined. Between 1994 and 2001 a total of 56 patients underwent cryosurgery with or without resection for primary and metastatic hepatobiliary malignancies. A 5-cm cryotherapy lollipop probe was used to ablate surgical margins less than one centimeter in 13 of these patients. There were seven colorectal metastases, three hepatocellular carcinomas, and three gallbladder carcinomas. The median size of the colorectal and hepatocellular lesions was 3 cm (range 2-14 cm), and all gallbladder primaries were T2 tumors. All tumors except three were located centrally in the liver requiring cryoablation of margins at segments 4, 5, and 8. Most patients had one site frozen (n = 9) with a median target temperature of -190°C and a median of two freeze-thaw cycles. Final pathological analysis of the resected specimens revealed nine close (
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M3 - Article
VL - 68
SP - 695
EP - 703
JO - American Surgeon
JF - American Surgeon
SN - 0003-1348
IS - 8
ER -