Cytokines and growth factors involved in apoptosis and proliferation of vascular smooth muscle cells

Kriti Rakesh, Devendra K. Agrawal

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

This review focuses on the role of cytokines and growth factors involved in the regulation of smooth muscle cells in an atherosclerotic plaque. As a plaque begins to develop, upon endothelial injury inflammatory cells within the lesion interact with the accumulating LDL, other inflammatory cells and smooth muscle cells and release cytokines and growth factors. The mediators released from the activated cells regulate the proliferation and/or survival of smooth muscle cells. This determines the stability and integrity of a plaque. New data emerging from various studies have provided novel insights into many of the cellular interactions and signaling mechanisms involving apoptosis of smooth muscle cells in the atherosclerotic plaques. A number of these studies, focusing on activation of inflammatory cells and the roles of chemokines, cytokines and growth factors, are addressed in this review.

Original languageEnglish
Pages (from-to)1487-1506
Number of pages20
JournalInternational Immunopharmacology
Volume5
Issue number10
DOIs
StatePublished - Sep 2005

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Vascular Smooth Muscle
Smooth Muscle Myocytes
Intercellular Signaling Peptides and Proteins
Apoptosis
Cytokines
Atherosclerotic Plaques
Chemokines
Cell Survival
Cell Proliferation
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Immunology
  • Pharmacology

Cite this

Cytokines and growth factors involved in apoptosis and proliferation of vascular smooth muscle cells. / Rakesh, Kriti; Agrawal, Devendra K.

In: International Immunopharmacology, Vol. 5, No. 10, 09.2005, p. 1487-1506.

Research output: Contribution to journalReview article

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