Cytoplasmic Ca2+ inhibits the glucose transporter of human erythrocytes

Y. P. Tu, L. Xiao, X. F. Su, F. Y. Yang

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Abstract

The effect of Ca2+ on the glucose transporter of human erythrocytes was investigated. The results showed that Ca2+ had no effect. But, the glucose transport of extracellular Ca2+ erythrocytes was markedly inhibited due to the increase in Ca2+ concentration by addition of ionophore A23187. The Ca2+ inhibition exhibited a dose-dependent manner with apparent half maximal concentration of 250 μM and could not be recovered by 10 mM EGTA. Unlike Ca2+ glucose transporter Mg2+ did not affect the glucose transporter.

Original languageEnglish (US)
Pages (from-to)383-391
Number of pages9
JournalBiochemistry and Molecular Biology International
Volume36
Issue number2
StatePublished - Dec 1 1995
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Genetics

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