Cytoplasmic Ca2+ inhibits the glucose transporter of human erythrocytes

Y. P. Tu; L. Xiao; X. F. Su; F. Y. Yang

Cytoplasmic Ca²⁺ inhibits the glucose transporter of human erythrocytes

Y. P. Tu, L. Xiao, X. F. Su, F. Y. Yang

Research output: Contribution to journal › Article › peer-review

Abstract

The effect of Ca²⁺ on the glucose transporter of human erythrocytes was investigated. The results showed that Ca²⁺ had no effect. But, the glucose transport of extracellular Ca²⁺ erythrocytes was markedly inhibited due to the increase in Ca²⁺ concentration by addition of ionophore A23187. The Ca²⁺ inhibition exhibited a dose-dependent manner with apparent half maximal concentration of 250 μM and could not be recovered by 10 mM EGTA. Unlike Ca²⁺ glucose transporter Mg²⁺ did not affect the glucose transporter.

Original language	English (US)
Pages (from-to)	383-391
Number of pages	9
Journal	Biochemistry and Molecular Biology International
Volume	36
Issue number	2
State	Published - Dec 1 1995
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Genetics

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abstract = "The effect of Ca2+ on the glucose transporter of human erythrocytes was investigated. The results showed that Ca2+ had no effect. But, the glucose transport of extracellular Ca2+ erythrocytes was markedly inhibited due to the increase in Ca2+ concentration by addition of ionophore A23187. The Ca2+ inhibition exhibited a dose-dependent manner with apparent half maximal concentration of 250 μM and could not be recovered by 10 mM EGTA. Unlike Ca2+ glucose transporter Mg2+ did not affect the glucose transporter.",

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N2 - The effect of Ca2+ on the glucose transporter of human erythrocytes was investigated. The results showed that Ca2+ had no effect. But, the glucose transport of extracellular Ca2+ erythrocytes was markedly inhibited due to the increase in Ca2+ concentration by addition of ionophore A23187. The Ca2+ inhibition exhibited a dose-dependent manner with apparent half maximal concentration of 250 μM and could not be recovered by 10 mM EGTA. Unlike Ca2+ glucose transporter Mg2+ did not affect the glucose transporter.

AB - The effect of Ca2+ on the glucose transporter of human erythrocytes was investigated. The results showed that Ca2+ had no effect. But, the glucose transport of extracellular Ca2+ erythrocytes was markedly inhibited due to the increase in Ca2+ concentration by addition of ionophore A23187. The Ca2+ inhibition exhibited a dose-dependent manner with apparent half maximal concentration of 250 μM and could not be recovered by 10 mM EGTA. Unlike Ca2+ glucose transporter Mg2+ did not affect the glucose transporter.

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