Data on TREM-1 activation destabilizing carotid plaques

Velidi H. Rao, Vikrant Rai, Samantha Stoupa, Saravanan Subramanian, Devendra K. Agrawal

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The data described herein are related to the article entitled "Tumor necrosis factor-α regulates triggering receptor expressed on myeloid cells-1-dependent matrix metalloproteinases in the carotid plaques of symptomatic patients with carotid stenosis" (Rao et al., 2016) [1]. Additional data are provided on the dose-response effect of TNF-α, TREM-1 antibody and recombinant rTREM-1/Fc fusion chimera (TREM-1/FC) on the expression of MMP-1 and MMP-9 in vascular smooth muscle cells (VSMCs) isolated from human carotid endarterectomy tissues. Data are also presented on the distribution of CD86+ M1- and CD206+ M2-macrophages and their co-localization with TREM-1 in symptomatic carotid plaques as visualized by dual immunofluorescence. The interpretation of this data and further extensive insights can be found in Rao et al. (2016) [1].

Original languageEnglish
Pages (from-to)230-234
Number of pages5
JournalData in Brief
StatePublished - Sep 1 2016

All Science Journal Classification (ASJC) codes

  • General
  • Education


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