DCAF1 (VprBP): emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor

N. Max Schabla, Koushik Mondal, Patrick C. Swanson

Research output: Contribution to journalArticle

Abstract

Cullin-RING ligases (CRLs) comprise a large group of modular eukaryotic E3 ubiquitin ligases. Within this family, the CRL4 ligase (consisting of the Cullin4 [CUL4] scaffold protein, the Rbx1 RING finger domain protein, the DNA damage-binding protein 1 [DDB1], and one of many DDB1-associated substrate receptor proteins) has been intensively studied in recent years due to its involvement in regulating various cellular processes, its role in cancer development and progression, and its subversion by viral accessory proteins. Initially discovered as a target for hijacking by the human immunodeficiency virus accessory protein r, the normal targets and function of the CRL4 substrate receptor protein DDB1-Cul4-associated factor 1 (DCAF1; also known as VprBP) had remained elusive, but newer studies have begun to shed light on these questions. Here, we review recent progress in understanding the diverse physiological roles of this DCAF1 in supporting various general and cell type-specific cellular processes in its context with the CRL4 E3 ligase, as well as another HECT-type E3 ligase with which DCAF1 also associates, called EDD/UBR5. We also discuss emerging questions and areas of future study to uncover the dynamic roles of DCAF1 in normal physiology.

Original languageEnglish (US)
Pages (from-to)725-735
Number of pages11
JournalJournal of molecular cell biology
Volume11
Issue number9
DOIs
StatePublished - Sep 19 2019

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Ubiquitin-Protein Ligases
DNA-Binding Proteins
DNA Damage
Ligases
Viral Regulatory and Accessory Proteins
Proteins
RING Finger Domains
Cullin Proteins
Human Immunodeficiency Virus Proteins
Neoplasms

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cell Biology

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DCAF1 (VprBP) : emerging physiological roles for a unique dual-service E3 ubiquitin ligase substrate receptor. / Schabla, N. Max; Mondal, Koushik; Swanson, Patrick C.

In: Journal of molecular cell biology, Vol. 11, No. 9, 19.09.2019, p. 725-735.

Research output: Contribution to journalArticle

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