Decoding IgE Fc receptors

Ming Zhang, Richard F. Murphy, Devendra K. Agrawal

    Research output: Contribution to journalReview articlepeer-review

    36 Scopus citations

    Abstract

    Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic diseases by interacting with two membrane receptors: high-affinity FcεRI and low-affinity FcεRII (CD23). Allergeninduced IgE-occupied FcεRI aggregation on the mast cell or basophil cell surface leads to the activation of intracellular signaling events and eventually the release of pre-formed and de novo synthesized inflammatory mediators. The role of FcεRII in allergic diseases has been proposed to include regulation of IgE synthesis, enhanced histamine release from basophils, and a contribution to Ag-IgE complex presentation but the exact function of CD23 remains poorly understood. This review summarizes some new developments in IgE Fc-receptor studies with an emphasis on regulation of FcεRI expression and signal transduction, including monomeric IgE, lipid raft segregation, and some recently identified negative regulators. A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively.

    Original languageEnglish
    Pages (from-to)1-16
    Number of pages16
    JournalImmunologic Research
    Volume37
    Issue number1
    DOIs
    StatePublished - Jan 2007

    All Science Journal Classification (ASJC) codes

    • Immunology

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