Decoding IgE Fc receptors

Ming Zhang, Richard F. Murphy, Devendra K. Agrawal

Research output: Contribution to journalReview article

35 Scopus citations

Abstract

Immunoglobulin E (IgE) plays a central role in the pathogenesis of allergic diseases by interacting with two membrane receptors: high-affinity FcεRI and low-affinity FcεRII (CD23). Allergeninduced IgE-occupied FcεRI aggregation on the mast cell or basophil cell surface leads to the activation of intracellular signaling events and eventually the release of pre-formed and de novo synthesized inflammatory mediators. The role of FcεRII in allergic diseases has been proposed to include regulation of IgE synthesis, enhanced histamine release from basophils, and a contribution to Ag-IgE complex presentation but the exact function of CD23 remains poorly understood. This review summarizes some new developments in IgE Fc-receptor studies with an emphasis on regulation of FcεRI expression and signal transduction, including monomeric IgE, lipid raft segregation, and some recently identified negative regulators. A better understanding of signaling events following IgE FcR aggregation will shed new light on how allergy patients might be treated more safely and effectively.

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All Science Journal Classification (ASJC) codes

  • Immunology

Cite this

Zhang, M., Murphy, R. F., & Agrawal, D. K. (2007). Decoding IgE Fc receptors. Immunologic Research, 37(1), 1-16. https://doi.org/10.1007/BF02686092