Decreased teicoplanin susceptibility of methicillin-resistant strains of staphylococcus aureus

Jean Luc Mainardi, David M. Shlaes, Richard V. Goering, Janet H. Shlaes, Jacques F. Acar, Fred W. Goldstein

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Between February 1992 and February 1993, 12 patients were seen who were infected or colonized with methicillin-resistant strains of Staphylococcus aureus. The strains had decreased susceptibility to teicoplanin (MICs, 816 g/mL). Field inversion gel electrophoresis showed the strains belonged to three related clones (A1A2and A3). The patients were thought to have acquired the strains nosocomially. Consistent with results of laboratory studies of teicoplanin-resistant S. aureus, all but 1 strain expressed a 35-kDa membrane protein, and 9 strains expressed increased levels of penicillin-binding protein 2 complex. Six strains were isolated from patients treated with glycopeptides. These data suggest that nosocomial transmission of S. aureus with decreased teicoplanin susceptibility may occur during glycopeptide use and that such strains develop resistance by a mechanism associated with the appearance of a 35-kDa membrane protein. Surveillance is necessary to monitor for the potential selection of resistant clones that may be capable of dissemination.

Original languageEnglish
Pages (from-to)1646-1650
Number of pages5
JournalJournal of Infectious Diseases
Volume171
Issue number6
DOIs
StatePublished - 1995

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Teicoplanin
Methicillin-Resistant Staphylococcus aureus
Glycopeptides
Staphylococcus aureus
Membrane Proteins
Clone Cells
Penicillin-Binding Proteins
Pulsed Field Gel Electrophoresis

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Decreased teicoplanin susceptibility of methicillin-resistant strains of staphylococcus aureus. / Mainardi, Jean Luc; Shlaes, David M.; Goering, Richard V.; Shlaes, Janet H.; Acar, Jacques F.; Goldstein, Fred W.

In: Journal of Infectious Diseases, Vol. 171, No. 6, 1995, p. 1646-1650.

Research output: Contribution to journalArticle

Mainardi, Jean Luc ; Shlaes, David M. ; Goering, Richard V. ; Shlaes, Janet H. ; Acar, Jacques F. ; Goldstein, Fred W. / Decreased teicoplanin susceptibility of methicillin-resistant strains of staphylococcus aureus. In: Journal of Infectious Diseases. 1995 ; Vol. 171, No. 6. pp. 1646-1650.
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