Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats

Deniz Yilmazer-Hanke, Marina Eliava, Joachim Hanke, Herbert Schwegler, Esther Asan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The cholinergic and dopaminergic innervation of the amygdala plays an important role in attention, emotional arousal, aversive forms of associative learning, conditioned responses, and stress responsivity. Roman High- (RHA) and Low-Avoidance (RLA) rats are an ideal model to study the potential impact of this innervation on behavioral responses, because they were selected bidirectionally for differences in their two-way active avoidance performance. RHA rats are known to quickly acquire two-way active avoidance and show indications of enhanced impulsive behavior, novelty seeking, and vulnerability to substance abuse, whereas RLA rats exhibit a passive coping style with high levels of immobility and enhanced stress responsivity. In the present study, the density of acetylcholine esterase (AchE)-positive cholinergic fibers and tyrosine hydroxylase immunoreactive (TH-ir) fibers were analyzed in various amygdala nuclei. In comparison to RLA rats, RHA rats displayed a significantly higher density of AchE-positive fibers in the lateral nucleus (La), the major sensory input area of the amygdala. In contrast, RLA rats showed a higher density of TH-ir fibers in the lateral division of the central nucleus (CeL), which modulates amygdala output and is known to contain more corticotropin-releasing hormone (CRH) positive neurons in RLA than in RHA rats. The findings suggest that a higher density of AchE-positive fibers in the La of RHA rats may facilitate attentional mechanisms and aversive forms of associative learning in RHA rats, whereas the increased density of TH-ir fibers in the CeL of RLA rats may be involved in the regulation of enhanced CRH expression and stress responsivity.

Original languageEnglish (US)
Pages (from-to)114-118
Number of pages5
JournalNeuroscience Letters
Volume632
DOIs
StatePublished - Oct 6 2016

Fingerprint

Tyrosine 3-Monooxygenase
Esterases
Amygdala
Acetylcholine
Corticotropin-Releasing Hormone
Cholinergic Fibers
Learning
Intralaminar Thalamic Nuclei
Impulsive Behavior
Arousal
Cholinergic Agents
Substance-Related Disorders
Neurons

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Medicine(all)

Cite this

Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats. / Yilmazer-Hanke, Deniz; Eliava, Marina; Hanke, Joachim; Schwegler, Herbert; Asan, Esther.

In: Neuroscience Letters, Vol. 632, 06.10.2016, p. 114-118.

Research output: Contribution to journalArticle

Yilmazer-Hanke, Deniz ; Eliava, Marina ; Hanke, Joachim ; Schwegler, Herbert ; Asan, Esther. / Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats. In: Neuroscience Letters. 2016 ; Vol. 632. pp. 114-118.
@article{78648aa1068a4e09a09ccb12b063cf47,
title = "Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats",
abstract = "The cholinergic and dopaminergic innervation of the amygdala plays an important role in attention, emotional arousal, aversive forms of associative learning, conditioned responses, and stress responsivity. Roman High- (RHA) and Low-Avoidance (RLA) rats are an ideal model to study the potential impact of this innervation on behavioral responses, because they were selected bidirectionally for differences in their two-way active avoidance performance. RHA rats are known to quickly acquire two-way active avoidance and show indications of enhanced impulsive behavior, novelty seeking, and vulnerability to substance abuse, whereas RLA rats exhibit a passive coping style with high levels of immobility and enhanced stress responsivity. In the present study, the density of acetylcholine esterase (AchE)-positive cholinergic fibers and tyrosine hydroxylase immunoreactive (TH-ir) fibers were analyzed in various amygdala nuclei. In comparison to RLA rats, RHA rats displayed a significantly higher density of AchE-positive fibers in the lateral nucleus (La), the major sensory input area of the amygdala. In contrast, RLA rats showed a higher density of TH-ir fibers in the lateral division of the central nucleus (CeL), which modulates amygdala output and is known to contain more corticotropin-releasing hormone (CRH) positive neurons in RLA than in RHA rats. The findings suggest that a higher density of AchE-positive fibers in the La of RHA rats may facilitate attentional mechanisms and aversive forms of associative learning in RHA rats, whereas the increased density of TH-ir fibers in the CeL of RLA rats may be involved in the regulation of enhanced CRH expression and stress responsivity.",
author = "Deniz Yilmazer-Hanke and Marina Eliava and Joachim Hanke and Herbert Schwegler and Esther Asan",
year = "2016",
month = "10",
day = "6",
doi = "10.1016/j.neulet.2016.08.053",
language = "English (US)",
volume = "632",
pages = "114--118",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Density of acetylcholine esterase (AchE) and tyrosine hydroxylase (TH) containing fibers in the amygdala of roman high- and low-avoidance rats

AU - Yilmazer-Hanke, Deniz

AU - Eliava, Marina

AU - Hanke, Joachim

AU - Schwegler, Herbert

AU - Asan, Esther

PY - 2016/10/6

Y1 - 2016/10/6

N2 - The cholinergic and dopaminergic innervation of the amygdala plays an important role in attention, emotional arousal, aversive forms of associative learning, conditioned responses, and stress responsivity. Roman High- (RHA) and Low-Avoidance (RLA) rats are an ideal model to study the potential impact of this innervation on behavioral responses, because they were selected bidirectionally for differences in their two-way active avoidance performance. RHA rats are known to quickly acquire two-way active avoidance and show indications of enhanced impulsive behavior, novelty seeking, and vulnerability to substance abuse, whereas RLA rats exhibit a passive coping style with high levels of immobility and enhanced stress responsivity. In the present study, the density of acetylcholine esterase (AchE)-positive cholinergic fibers and tyrosine hydroxylase immunoreactive (TH-ir) fibers were analyzed in various amygdala nuclei. In comparison to RLA rats, RHA rats displayed a significantly higher density of AchE-positive fibers in the lateral nucleus (La), the major sensory input area of the amygdala. In contrast, RLA rats showed a higher density of TH-ir fibers in the lateral division of the central nucleus (CeL), which modulates amygdala output and is known to contain more corticotropin-releasing hormone (CRH) positive neurons in RLA than in RHA rats. The findings suggest that a higher density of AchE-positive fibers in the La of RHA rats may facilitate attentional mechanisms and aversive forms of associative learning in RHA rats, whereas the increased density of TH-ir fibers in the CeL of RLA rats may be involved in the regulation of enhanced CRH expression and stress responsivity.

AB - The cholinergic and dopaminergic innervation of the amygdala plays an important role in attention, emotional arousal, aversive forms of associative learning, conditioned responses, and stress responsivity. Roman High- (RHA) and Low-Avoidance (RLA) rats are an ideal model to study the potential impact of this innervation on behavioral responses, because they were selected bidirectionally for differences in their two-way active avoidance performance. RHA rats are known to quickly acquire two-way active avoidance and show indications of enhanced impulsive behavior, novelty seeking, and vulnerability to substance abuse, whereas RLA rats exhibit a passive coping style with high levels of immobility and enhanced stress responsivity. In the present study, the density of acetylcholine esterase (AchE)-positive cholinergic fibers and tyrosine hydroxylase immunoreactive (TH-ir) fibers were analyzed in various amygdala nuclei. In comparison to RLA rats, RHA rats displayed a significantly higher density of AchE-positive fibers in the lateral nucleus (La), the major sensory input area of the amygdala. In contrast, RLA rats showed a higher density of TH-ir fibers in the lateral division of the central nucleus (CeL), which modulates amygdala output and is known to contain more corticotropin-releasing hormone (CRH) positive neurons in RLA than in RHA rats. The findings suggest that a higher density of AchE-positive fibers in the La of RHA rats may facilitate attentional mechanisms and aversive forms of associative learning in RHA rats, whereas the increased density of TH-ir fibers in the CeL of RLA rats may be involved in the regulation of enhanced CRH expression and stress responsivity.

UR - http://www.scopus.com/inward/record.url?scp=84984799799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84984799799&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2016.08.053

DO - 10.1016/j.neulet.2016.08.053

M3 - Article

VL - 632

SP - 114

EP - 118

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -