Depression in women: Diagnostic and treatment considerations

Research output: Contribution to journalArticle

Abstract

Twice as many women experience depression as men. Family physicians should take gender-related biopsychosocial differ-ences and phases of the reproductive cycle into consideration when evaluating and treating depression in women. Although the same diagnostic criteria are used for both genders, the presentation and course may differ in women. Women may more often experience hypersomnia, hyperphagia, guilt, anxiety, weight gain, and comorbid eating disorders. Women may require lower dosages of antidepressants than men because plasma antidepressant concentrations may be higher due to biological differences such as hormone levels and body fat to muscle ratio. The potential effects of antidepressants on a fetus or neonate are a consideration for many depressed women. No increased teratogenic risk from in utero exposure to selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants has been shown by research studies. SSRIs have been shown effective in treating premenstrual dysphoric disorder and other comorbid conditions associated with depression. In women with mild-to-moderate depression, psychotherapy may be the sole treatment, or psychotherapy may be used adjunctively with antidepressant drug therapy. Every patient with depression should be screened for suicidal thoughts, intent, and plan during the initial visit. According to the authors, severely depressed women who have active suicidal thoughts or plans should usually be managed in conjunction with a psychiatrist.

Original languageEnglish
Pages (from-to)65
Number of pages1
JournalPrimary Care Companion to the Journal of Clinical Psychiatry
Volume2
Issue number2
StatePublished - 2000

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Depression
Antidepressive Agents
Serotonin Uptake Inhibitors
Therapeutics
Psychotherapy
Disorders of Excessive Somnolence
Hyperphagia
Guilt
Tricyclic Antidepressive Agents
Family Physicians
Weight Gain
Psychiatry
Adipose Tissue
Fetus
Anxiety
Newborn Infant
Hormones
Drug Therapy
Muscles
Research

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

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title = "Depression in women: Diagnostic and treatment considerations",
abstract = "Twice as many women experience depression as men. Family physicians should take gender-related biopsychosocial differ-ences and phases of the reproductive cycle into consideration when evaluating and treating depression in women. Although the same diagnostic criteria are used for both genders, the presentation and course may differ in women. Women may more often experience hypersomnia, hyperphagia, guilt, anxiety, weight gain, and comorbid eating disorders. Women may require lower dosages of antidepressants than men because plasma antidepressant concentrations may be higher due to biological differences such as hormone levels and body fat to muscle ratio. The potential effects of antidepressants on a fetus or neonate are a consideration for many depressed women. No increased teratogenic risk from in utero exposure to selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants has been shown by research studies. SSRIs have been shown effective in treating premenstrual dysphoric disorder and other comorbid conditions associated with depression. In women with mild-to-moderate depression, psychotherapy may be the sole treatment, or psychotherapy may be used adjunctively with antidepressant drug therapy. Every patient with depression should be screened for suicidal thoughts, intent, and plan during the initial visit. According to the authors, severely depressed women who have active suicidal thoughts or plans should usually be managed in conjunction with a psychiatrist.",
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