Deregulation of MUC4 in gastric adenocarcinoma: Potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer

S. Senapati, P. Chaturvedi, P. Sharma, G. Venkatraman, J. L. Meza, W. El-Rifai, H. K. Roy, S. K. Batra

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers. To date, no extensive study has been done to check the expression and functional significance of MUC4 in different types of gastric adenocarcinomas. Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells. Immunohistochemical analysis using tissue microarray (TMA) showed a significant difference in MUC4 expression between normal adjacent (n=45) and gastric adenocarcinoma (n=83; P

Original languageEnglish (US)
Pages (from-to)949-956
Number of pages8
JournalBritish Journal of Cancer
Volume99
Issue number6
DOIs
StatePublished - Sep 16 2008

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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