Deregulation of MUC4 in gastric adenocarcinoma: Potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer

S. Senapati; P. Chaturvedi; P. Sharma; G. Venkatraman; J. L. Meza; W. El-Rifai; H. K. Roy; S. K. Batra

doi:10.1038/sj.bjc.6604632

Deregulation of MUC4 in gastric adenocarcinoma: Potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer

S. Senapati, P. Chaturvedi, P. Sharma, G. Venkatraman, J. L. Meza, W. El-Rifai, H. K. Roy, S. K. Batra

Department of Pathology

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers. To date, no extensive study has been done to check the expression and functional significance of MUC4 in different types of gastric adenocarcinomas. Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells. Immunohistochemical analysis using tissue microarray (TMA) showed a significant difference in MUC4 expression between normal adjacent (n=45) and gastric adenocarcinoma (n=83; P

Original language	English (US)
Pages (from-to)	949-956
Number of pages	8
Journal	British Journal of Cancer
Volume	99
Issue number	6
DOIs	https://doi.org/10.1038/sj.bjc.6604632
State	Published - Sep 16 2008

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

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title = "Deregulation of MUC4 in gastric adenocarcinoma: Potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer",

abstract = "MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers. To date, no extensive study has been done to check the expression and functional significance of MUC4 in different types of gastric adenocarcinomas. Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells. Immunohistochemical analysis using tissue microarray (TMA) showed a significant difference in MUC4 expression between normal adjacent (n=45) and gastric adenocarcinoma (n=83; P",

author = "S. Senapati and P. Chaturvedi and P. Sharma and G. Venkatraman and Meza, {J. L.} and W. El-Rifai and Roy, {H. K.} and Batra, {S. K.}",

note = "Funding Information: This work was supported by grants from the National Institutes of Health (CA78590, CA111294). We thank Ms Kristi L Berger for editing the paper. The invaluable technical support of Mr Erik Moore was greatly appreciated.",

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AU - Senapati, S.

AU - Chaturvedi, P.

AU - Sharma, P.

AU - Venkatraman, G.

AU - Meza, J. L.

AU - El-Rifai, W.

AU - Roy, H. K.

AU - Batra, S. K.

N1 - Funding Information: This work was supported by grants from the National Institutes of Health (CA78590, CA111294). We thank Ms Kristi L Berger for editing the paper. The invaluable technical support of Mr Erik Moore was greatly appreciated.

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N2 - MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers. To date, no extensive study has been done to check the expression and functional significance of MUC4 in different types of gastric adenocarcinomas. Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells. Immunohistochemical analysis using tissue microarray (TMA) showed a significant difference in MUC4 expression between normal adjacent (n=45) and gastric adenocarcinoma (n=83; P

AB - MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers. To date, no extensive study has been done to check the expression and functional significance of MUC4 in different types of gastric adenocarcinomas. Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells. Immunohistochemical analysis using tissue microarray (TMA) showed a significant difference in MUC4 expression between normal adjacent (n=45) and gastric adenocarcinoma (n=83; P

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Deregulation of MUC4 in gastric adenocarcinoma: Potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer

Abstract

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