Abstract
MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers. To date, no extensive study has been done to check the expression and functional significance of MUC4 in different types of gastric adenocarcinomas. Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells. Immunohistochemical analysis using tissue microarray (TMA) showed a significant difference in MUC4 expression between normal adjacent (n=45) and gastric adenocarcinoma (n=83; P
| Original language | English |
|---|---|
| Pages (from-to) | 949-956 |
| Number of pages | 8 |
| Journal | British Journal of Cancer |
| Volume | 99 |
| Issue number | 6 |
| DOIs | |
| State | Published - Sep 16 2008 |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Oncology
Cite this
Deregulation of MUC4 in gastric adenocarcinoma : Potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer. / Senapati, S.; Chaturvedi, P.; Sharma, Poonam K; Venkatraman, G.; Meza, J. L.; El-Rifai, W.; Roy, H. K.; Batra, S. K.
In: British Journal of Cancer, Vol. 99, No. 6, 16.09.2008, p. 949-956.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Deregulation of MUC4 in gastric adenocarcinoma
T2 - Potential pathobiological implication in poorly differentiated non-signet ring cell type gastric cancer
AU - Senapati, S.
AU - Chaturvedi, P.
AU - Sharma, Poonam K
AU - Venkatraman, G.
AU - Meza, J. L.
AU - El-Rifai, W.
AU - Roy, H. K.
AU - Batra, S. K.
PY - 2008/9/16
Y1 - 2008/9/16
N2 - MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers. To date, no extensive study has been done to check the expression and functional significance of MUC4 in different types of gastric adenocarcinomas. Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells. Immunohistochemical analysis using tissue microarray (TMA) showed a significant difference in MUC4 expression between normal adjacent (n=45) and gastric adenocarcinoma (n=83; P
AB - MUC4 is a large, heavily glycosylated transmembrane mucin, that is implicated in the pathogenesis of various types of cancers. To date, no extensive study has been done to check the expression and functional significance of MUC4 in different types of gastric adenocarcinomas. Here, we report the expression profile of MUC4 in gastric adenocarcinomas and its function in poorly differentiated gastric non-signet ring cell carcinoma (non-SRCC) type cells. Immunohistochemical analysis using tissue microarray (TMA) showed a significant difference in MUC4 expression between normal adjacent (n=45) and gastric adenocarcinoma (n=83; P
UR - http://www.scopus.com/inward/record.url?scp=51449094984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51449094984&partnerID=8YFLogxK
U2 - 10.1038/sj.bjc.6604632
DO - 10.1038/sj.bjc.6604632
M3 - Article
C2 - 18781152
AN - SCOPUS:51449094984
VL - 99
SP - 949
EP - 956
JO - British Journal of Cancer
JF - British Journal of Cancer
SN - 0007-0920
IS - 6
ER -