Design Considerations for Clinical Investigations of Osteoporosis

Robert P. Heaney

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is a commonplace of both clinical and investigative experience that things vary. No two individuals have quite the same bone size or density. Neither do bone mineral content (BMC) and remodeling activity respond to an intervention equally in every individual treated with a given agent. Moreover, the patients enrolled in an investigation of a new treatment for osteoporosis may differ, not only from one another, but from the larger group of patients the drug is intended to treat. Finally, those patients selected by their physicians to receive a particular treatment (e.g., hormone replacement therapy) may be different from those not selected. (Indeed, it would be hoped that the treatment choices by physicians and patients had a rational basis and were not decided by flips of a coin.).

Original languageEnglish (US)
Title of host publicationOsteoporosis
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Pages1753-1776
Number of pages24
ISBN (Print)9780124158535
DOIs
StatePublished - Jun 2013

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Medicine(all)

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  • Cite this

    Heaney, R. P. (2013). Design Considerations for Clinical Investigations of Osteoporosis. In Osteoporosis: Fourth Edition (pp. 1753-1776). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-415853-5.00075-3