Determinants of endogenous calcium entry into the gut

K. Michael Davies, Karen Rafferty, Robert P. Heaney

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: In addition to food sources, calcium enters the gut by way of digestive secretions and shed mucosa. In health, such entry is as large as or larger than urinary calcium excretion. Because calcium absorption is inefficient, most of this endogenous intestinal calcium is excreted. Objective: Our aim was to determine the dietary, anthropometric, and physiologic determinants of calcium entering the digestive stream from endogenous sources. Design: Multiple regression modeling of intake and excretion data was used with 553 metabolic balance and kinetics studies performed in 190 midlife, white women. Results: Endogenous intestinal calcium averaged 3.29 ± 0.83 mmol/d. Multiple regression models explaining variation in this endogenous intestinal calcium were developed with use of dietary intake, anthropometric, and serum mineral variables. All 3 groups of predictor variables individually explained up to 22% of the variation in measured values for endogenous intestinal calcium. A composite model, incorporating all 3 groups explained 29% of the variation, with phosphorus and meat protein intakes, height, weight, and serum calcium and phosphorus concentrations all independently entering the model. Phosphorus intake dominated over all the other predictors, explaining 20% of the variance all by itself, with endogenous intestinal calcium rising by 0.037 mmol for every 1 mmol of phosphorus ingested. Meat protein (but not nonmeat protein) was the only other significant dietary contributor, exhibiting a negative coefficient. Conclusion: As a first approximation, the amount of endogenous calcium entering the digestive stream rises with body size and with the amount of phosphorus-rich food consumed.

Original languageEnglish
Pages (from-to)919-923
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume80
Issue number4
StatePublished - Oct 2004

Fingerprint

digestive system
Calcium
calcium
Phosphorus
phosphorus
meat protein
Meat
excretion
endogenous sources
Food
Proteins
sheds
Body Size
Serum
protein intake
mucosa
Minerals
food intake
Mucous Membrane
body size

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Food Science

Cite this

Davies, K. M., Rafferty, K., & Heaney, R. P. (2004). Determinants of endogenous calcium entry into the gut. American Journal of Clinical Nutrition, 80(4), 919-923.

Determinants of endogenous calcium entry into the gut. / Davies, K. Michael; Rafferty, Karen; Heaney, Robert P.

In: American Journal of Clinical Nutrition, Vol. 80, No. 4, 10.2004, p. 919-923.

Research output: Contribution to journalArticle

Davies, KM, Rafferty, K & Heaney, RP 2004, 'Determinants of endogenous calcium entry into the gut', American Journal of Clinical Nutrition, vol. 80, no. 4, pp. 919-923.
Davies KM, Rafferty K, Heaney RP. Determinants of endogenous calcium entry into the gut. American Journal of Clinical Nutrition. 2004 Oct;80(4):919-923.
Davies, K. Michael ; Rafferty, Karen ; Heaney, Robert P. / Determinants of endogenous calcium entry into the gut. In: American Journal of Clinical Nutrition. 2004 ; Vol. 80, No. 4. pp. 919-923.
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