Determination of bone size of hip, spine, and wrist in human pedigrees by genetic and lifestyle factors

Hong Wen Deng, Xu Tao Deng, Theresa Conway, Fu Hua Xu, Robert Heaney, Robert R. Recker

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Osteoporosis is a major public health problem defined as a loss of bone strength, of which bone size is an important determinant. Compared with extensive studies on bone mass, studies on the importance of factors determining variation in bone size are relatively few. In particular, the significance of genetic factors is largely unknown. In 49 pedigrees with 703 subjects bone sizes of the hip, spine, and wrist were measured by dual X-ray absorptiometry. We evaluated the contribution of genetic factors in determining variation in bone size of the hip, spine, and wrist while studying age, sex, weight, height, exercise, smoking, alcohol consumption, and the interaction among these factors as covariates for their effects on bone size. We found that, on average, males have larger bone sizes. Male bone sizes at the spine and hip increased with age; however, the effect of age in our female subjects was nonsignificant. Height invariably affected bone size at all the sites studied. Alcohol consumption and exercise generally had significant effects in increasing bone size at the spine and/or hip in both males and females. After adjusting for sex, age, weight, height, lifestyle factors, and the significant interactions among these factors, heritabilities (±SE) were, respectively, 0.48 (0.09), 0.64 (0.08), and 0.60 (0.09) for bone size at the hip, spine, and wrist.

Original languageEnglish
Pages (from-to)45-56
Number of pages12
JournalJournal of Clinical Densitometry
Volume5
Issue number1
Publication statusPublished - 2002

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Radiology Nuclear Medicine and imaging

Cite this