Determination of the physical state of drug in microcapsule and microsphere formulations

Research output: Contribution to journalArticle

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Abstract

Tolnaftate microcapsules and microspheres were prepared by gelatin-acacia coacervation and emulsion-solvent evaporation methods respectively. The physical state of the drug in these formulations was determined by using scanning electron microscopy (SEM), X-ray powder diffractometry, and differential scanning calorimetry (DSC). High pressure liquid chromatographic (HPLC) method was used for stability determination and polymer-drug interactions were evaluated using FTIR. The pros and cons of each method, in the assessment of the physical state of drug in these formulations, were investigated. SEM was found to be useful in obtaining a direct visual evidence of the presence of crystalline drug in the microspheres, but not for the microcapsule formulation. The DSC method was used to determine the physical state of the drug qualitatively in both these formulations. In the case of the microcapsules, accurate quantitation of the crystalline drug content by DSC was not possible because of the interference of thermal events. Powder X-ray diffractometric method was able to demonstrate the presence of crystalline drug and polymorphic changes, if any, in both these formulations. HPLC data revealed that the drug was stable in these formulations for at least 6 months. The FTIR studies indicated the absence of any drug interaction with the polymeric matrix materials, during preparation of these dosage forms.

Original languageEnglish
Pages (from-to)101-102
Number of pages2
JournalJournal of Microencapsulation
Volume14
Issue number1
StatePublished - Jan 1997

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Microspheres
Drug interactions
Capsules
Differential scanning calorimetry
drugs
Crystalline materials
Differential Scanning Calorimetry
formulations
Drug Compounding
Pharmaceutical Preparations
Powders
X rays
Fourier Transform Infrared Spectroscopy
Scanning electron microscopy
Drug Interactions
Electron Scanning Microscopy
Liquids
Tolnaftate
Emulsions
X-Rays

All Science Journal Classification (ASJC) codes

  • Chemical Engineering(all)
  • Chemistry (miscellaneous)
  • Pharmaceutical Science
  • Pharmacology

Cite this

Determination of the physical state of drug in microcapsule and microsphere formulations. / Dash, Alekha K.

In: Journal of Microencapsulation, Vol. 14, No. 1, 01.1997, p. 101-102.

Research output: Contribution to journalArticle

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