Determination of trace aluminum in urine by neutron activation analysis

A. J. Blotcky, D. Hobson, J. A. Leffler, E. P. Rack, Robert R. Recker

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Trace aluminum determination in biological material is difficult because of the very low levels generally present and the fact that significant quantities of aluminum are present in all reagents and the laboratory environment. A cation exchange chromatography procedure is outlined for the simple and quantitative determination of trace amounts of aluminum (i.e., ≥ 0.05 μg Al/ml urine) in biological material, employing 28Al neutron activation analysis. The procedure, utilizing a low power nuclear reactor ( 3.1 x 10 11 n/cm 2 s), consists of a) wet digestion of the biological material, b) cation exchange chromatography employing 1 M nitric acid to remove the major radiocontaminants sodium, chloride, silicate, and phosphate ions, and c) irradiation and radioassay of the aluminum contained in the resin. The aluminum concentration in normal urine samples varied from <0.05 to 0.13 μg/Al/ml. the precision of this method is such that we can measure with confidence aluminum levels of 0.05 μg/ml or above.

Original languageEnglish (US)
Pages (from-to)1084-1088
Number of pages5
JournalAnalytical Chemistry
Volume48
Issue number7
DOIs
StatePublished - 1976

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Neutron activation analysis
Aluminum
Biological materials
Chromatography
Cations
Nitric Acid
Silicates
Nuclear reactors
Sodium Chloride
Resins
Phosphates
Irradiation
Ions

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Cite this

Determination of trace aluminum in urine by neutron activation analysis. / Blotcky, A. J.; Hobson, D.; Leffler, J. A.; Rack, E. P.; Recker, Robert R.

In: Analytical Chemistry, Vol. 48, No. 7, 1976, p. 1084-1088.

Research output: Contribution to journalArticle

Blotcky, A. J. ; Hobson, D. ; Leffler, J. A. ; Rack, E. P. ; Recker, Robert R. / Determination of trace aluminum in urine by neutron activation analysis. In: Analytical Chemistry. 1976 ; Vol. 48, No. 7. pp. 1084-1088.
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