Determination of Trace Aluminum in Urine by Neutron Activation Analysis

A. J. Blotcky, D. Hobson, J. A. Leffler, E. P. Rack, R. R. Recker

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Trace aluminum determination in biological material is difficult because of the very low levels generally present and the fact that significant quantities of aluminum are present in all reagents and the laboratory environment. A cation-exchange chromatography procedure is outlined for the simple and quantitative determination of trace amounts of aluminum (i.e., ≥0.05 μg Al/ml urine) in biological material, employing 28Al neutron activation analysis. The procedure, utilizing a lowpower nuclear reactor (~3.1 × 1011n/cm2-s), consists of a) wet digestion of the biological material, b) cation-exchange chromatography employing 1 M nitric acid to remove the major radiocontaminants sodium, chloride, silicate, and phosphate ions, and c) irradiation and radioassay of the aluminum contained in the resin. The aluminum concentration in normal urine samples varied from <0.05 to 0.13 μg Al/ml. The precision of this method is such that we can measure with confidence aluminum levels of 0.05 μg/ml or above.

Original languageEnglish (US)
Pages (from-to)1084-1088
Number of pages5
JournalAnalytical Chemistry
Volume48
Issue number7
DOIs
StatePublished - Jun 1 1976

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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