Development and evolution of inner ear sensory epithelia and their innervation

B. Fritzsch, Kirk Beisel, K. Jones, I. Farias, A. Maklad, J. Lee, L. F. Reichardt

Research output: Contribution to journalReview article

120 Citations (Scopus)

Abstract

The development and evolution of the inner ear sensory patches and their innervation is reviewed. Recent molecular developmental data suggest that development of these sensory patches is a developmental recapitulation of the evolutionary history. These data suggest that the ear generates multiple, functionally diverse sensory epithelia by dividing a single sensory primordium. Those epithelia will establish distinct identities through the overlapping expression of genes of which only a few are currently known. One of these distinctions is the unique pattern of hair cell polarity. A hypothesis is presented on how the hair cell polarity may relate to the progressive segregation of the six sensory epithelia. Besides being markers for sensory epithelia development, neurotrophins are also expressed in delaminating cells that migrate toward the developing vestibular and cochlear ganglia. These delaminating cells originate from multiple sites at or near the developing sensory epithelia and some also express neuronal markers such as NeuroD. The differential origin of precursors raises the possibility that some sensory neurons acquire positional information before they delaminate the ear. Such an identity of these delaminating sensory neurons may be used both to navigate their dendrites to the area they delaminated from, as well as to help them navigate to their central target. The navigational properties of sensory neurons as well as the acquisition of discrete sensory patch phenotypes implies a much more sophisticated subdivision of the developing otocyst than the few available gene expression studies suggest.

Original languageEnglish
Pages (from-to)143-156
Number of pages14
JournalJournal of Neurobiology
Volume53
Issue number2
DOIs
StatePublished - Nov 5 2002

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Inner Ear
Epithelium
Sensory Receptor Cells
Cell Polarity
Ear
Overlapping Genes
Cochlea
Nerve Growth Factors
Dendrites
Ganglia
History
Phenotype
Gene Expression

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Fritzsch, B., Beisel, K., Jones, K., Farias, I., Maklad, A., Lee, J., & Reichardt, L. F. (2002). Development and evolution of inner ear sensory epithelia and their innervation. Journal of Neurobiology, 53(2), 143-156. https://doi.org/10.1002/neu.10098

Development and evolution of inner ear sensory epithelia and their innervation. / Fritzsch, B.; Beisel, Kirk; Jones, K.; Farias, I.; Maklad, A.; Lee, J.; Reichardt, L. F.

In: Journal of Neurobiology, Vol. 53, No. 2, 05.11.2002, p. 143-156.

Research output: Contribution to journalReview article

Fritzsch, B, Beisel, K, Jones, K, Farias, I, Maklad, A, Lee, J & Reichardt, LF 2002, 'Development and evolution of inner ear sensory epithelia and their innervation', Journal of Neurobiology, vol. 53, no. 2, pp. 143-156. https://doi.org/10.1002/neu.10098
Fritzsch, B. ; Beisel, Kirk ; Jones, K. ; Farias, I. ; Maklad, A. ; Lee, J. ; Reichardt, L. F. / Development and evolution of inner ear sensory epithelia and their innervation. In: Journal of Neurobiology. 2002 ; Vol. 53, No. 2. pp. 143-156.
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