Dextrorotatory opioids and phencyclidine exert anticonvulsant action in prepiriform cortex

Jane E. Roth, Ge Zhang, Thomas F. Murray, Paul H. Franklin

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We have investigated the ability of an array of putative noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists to suppress convulsions induced by a unilateral, focal injection of (-)-bicuculline methiodide (118 pmol) into the rat prepiriform cortex. The anticonvulsant potency of these compounds, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)>dextrorphan ≥ 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP)>dextromethorphan > (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P <0.01) with their respectiv affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes. These results suggest that noncompetitive antagonism of NMDA receptors underlies the anticonvulsant action of these compounds.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalEuropean Journal of Pharmacology
Volume215
Issue number2-3
DOIs
StatePublished - May 14 1992
Externally publishedYes

Fingerprint

Phencyclidine
Dextrorphan
N-Methyl-D-Aspartate Receptors
Anticonvulsants
Opioid Analgesics
Dextromethorphan
Pentazocine
Imines
Dizocilpine Maleate
Microinjections
Prosencephalon
Seizures
Injections
Membranes
Piriform Cortex

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Dextrorotatory opioids and phencyclidine exert anticonvulsant action in prepiriform cortex. / Roth, Jane E.; Zhang, Ge; Murray, Thomas F.; Franklin, Paul H.

In: European Journal of Pharmacology, Vol. 215, No. 2-3, 14.05.1992, p. 293-296.

Research output: Contribution to journalArticle

@article{aac2edad7b3b46f5835f87d0acd05593,
title = "Dextrorotatory opioids and phencyclidine exert anticonvulsant action in prepiriform cortex",
abstract = "We have investigated the ability of an array of putative noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists to suppress convulsions induced by a unilateral, focal injection of (-)-bicuculline methiodide (118 pmol) into the rat prepiriform cortex. The anticonvulsant potency of these compounds, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)>dextrorphan ≥ 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP)>dextromethorphan > (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P <0.01) with their respectiv affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes. These results suggest that noncompetitive antagonism of NMDA receptors underlies the anticonvulsant action of these compounds.",
author = "Roth, {Jane E.} and Ge Zhang and Murray, {Thomas F.} and Franklin, {Paul H.}",
year = "1992",
month = "5",
day = "14",
doi = "10.1016/0014-2999(92)90042-3",
language = "English",
volume = "215",
pages = "293--296",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2-3",

}

TY - JOUR

T1 - Dextrorotatory opioids and phencyclidine exert anticonvulsant action in prepiriform cortex

AU - Roth, Jane E.

AU - Zhang, Ge

AU - Murray, Thomas F.

AU - Franklin, Paul H.

PY - 1992/5/14

Y1 - 1992/5/14

N2 - We have investigated the ability of an array of putative noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists to suppress convulsions induced by a unilateral, focal injection of (-)-bicuculline methiodide (118 pmol) into the rat prepiriform cortex. The anticonvulsant potency of these compounds, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)>dextrorphan ≥ 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP)>dextromethorphan > (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P <0.01) with their respectiv affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes. These results suggest that noncompetitive antagonism of NMDA receptors underlies the anticonvulsant action of these compounds.

AB - We have investigated the ability of an array of putative noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists to suppress convulsions induced by a unilateral, focal injection of (-)-bicuculline methiodide (118 pmol) into the rat prepiriform cortex. The anticonvulsant potency of these compounds, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)>dextrorphan ≥ 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP)>dextromethorphan > (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P <0.01) with their respectiv affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes. These results suggest that noncompetitive antagonism of NMDA receptors underlies the anticonvulsant action of these compounds.

UR - http://www.scopus.com/inward/record.url?scp=0026507068&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026507068&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(92)90042-3

DO - 10.1016/0014-2999(92)90042-3

M3 - Article

VL - 215

SP - 293

EP - 296

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2-3

ER -