Dextrorotatory opioids and phencyclidine exert anticonvulsant action in prepiriform cortex

Jane E. Roth, Ge Zhang, Thomas F. Murray, Paul H. Franklin

Research output: Contribution to journalArticle

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Abstract

We have investigated the ability of an array of putative noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists to suppress convulsions induced by a unilateral, focal injection of (-)-bicuculline methiodide (118 pmol) into the rat prepiriform cortex. The anticonvulsant potency of these compounds, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)>dextrorphan ≥ 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP)>dextromethorphan > (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P <0.01) with their respectiv affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes. These results suggest that noncompetitive antagonism of NMDA receptors underlies the anticonvulsant action of these compounds.

Original languageEnglish
Pages (from-to)293-296
Number of pages4
JournalEuropean Journal of Pharmacology
Volume215
Issue number2-3
DOIs
Publication statusPublished - May 14 1992
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Pharmacology

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