Abstract
We have investigated the ability of an array of putative noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists to suppress convulsions induced by a unilateral, focal injection of (-)-bicuculline methiodide (118 pmol) into the rat prepiriform cortex. The anticonvulsant potency of these compounds, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)>dextrorphan ≥ 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP)>dextromethorphan > (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P <0.01) with their respectiv affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes. These results suggest that noncompetitive antagonism of NMDA receptors underlies the anticonvulsant action of these compounds.
| Original language | English |
|---|---|
| Pages (from-to) | 293-296 |
| Number of pages | 4 |
| Journal | European Journal of Pharmacology |
| Volume | 215 |
| Issue number | 2-3 |
| DOIs | |
| State | Published - May 14 1992 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Cellular and Molecular Neuroscience
- Pharmacology
Cite this
Dextrorotatory opioids and phencyclidine exert anticonvulsant action in prepiriform cortex. / Roth, Jane E.; Zhang, Ge; Murray, Thomas F.; Franklin, Paul H.
In: European Journal of Pharmacology, Vol. 215, No. 2-3, 14.05.1992, p. 293-296.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dextrorotatory opioids and phencyclidine exert anticonvulsant action in prepiriform cortex
AU - Roth, Jane E.
AU - Zhang, Ge
AU - Murray, Thomas F.
AU - Franklin, Paul H.
PY - 1992/5/14
Y1 - 1992/5/14
N2 - We have investigated the ability of an array of putative noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists to suppress convulsions induced by a unilateral, focal injection of (-)-bicuculline methiodide (118 pmol) into the rat prepiriform cortex. The anticonvulsant potency of these compounds, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)>dextrorphan ≥ 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP)>dextromethorphan > (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P <0.01) with their respectiv affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes. These results suggest that noncompetitive antagonism of NMDA receptors underlies the anticonvulsant action of these compounds.
AB - We have investigated the ability of an array of putative noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists to suppress convulsions induced by a unilateral, focal injection of (-)-bicuculline methiodide (118 pmol) into the rat prepiriform cortex. The anticonvulsant potency of these compounds, (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrogen maleate (MK-801)>dextrorphan ≥ 1-(1-phenylcyclohexyl)piperidine hydrochloride (PCP)>dextromethorphan > (+)-pentazocine, upon microinjection into the prepiriform cortex, was highly correlated (r = 0.971; P <0.01) with their respectiv affinities for the [3H]dextrorphan-labelled NMDA receptors in rat forebrain membranes. These results suggest that noncompetitive antagonism of NMDA receptors underlies the anticonvulsant action of these compounds.
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U2 - 10.1016/0014-2999(92)90042-3
DO - 10.1016/0014-2999(92)90042-3
M3 - Article
VL - 215
SP - 293
EP - 296
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -