Diagnosis and treatment of complicated tubercular meningitis

Julia J. Kelly, Edward A. Horowitz, Christopher J. Destache, Alan H. Fruin, Vicki A. Long

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A 41-year-old woman was seen in no acute distress with an infected ventriculoperitoneal shunt. She underwent several revisions of the shunt but was readmitted to the hospital with nausea, vomiting, and neurologic sequelae. Results of spinal fluid analysis were white blood cells 68/mm3 (25% neutrophils), glucose less than 20 mg/dl, and protein 513 mg/dl. Cerebrospinal fluid, aerobic and anaerobic, and blood cultures were negative. Three weeks later the patient suffered a seizure and was prescribed antitubercular agents for a presumed diagnosis of tubercular meningitis. One week later, chest wound culture from her first visit suggested Mycobacterium tuberculosis, which was confirmed by DNA probe; cerebrospinal fluid culture eventually grew the organism. The patient fared well once she received antituberculosis agents. The time between first contact and treatment in the hospital delayed therapy.

Original languageEnglish
Pages (from-to)1167-1172
Number of pages6
JournalPharmacotherapy
Volume19
Issue number10
DOIs
StatePublished - 1999

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Meningeal Tuberculosis
Cerebrospinal Fluid
Antitubercular Agents
Ventriculoperitoneal Shunt
DNA Probes
Mycobacterium tuberculosis
Nausea
Nervous System
Vomiting
Seizures
Neutrophils
Leukocytes
Thorax
Glucose
Wounds and Injuries
Therapeutics
Proteins
Blood Culture

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Diagnosis and treatment of complicated tubercular meningitis. / Kelly, Julia J.; Horowitz, Edward A.; Destache, Christopher J.; Fruin, Alan H.; Long, Vicki A.

In: Pharmacotherapy, Vol. 19, No. 10, 1999, p. 1167-1172.

Research output: Contribution to journalArticle

Kelly, JJ, Horowitz, EA, Destache, CJ, Fruin, AH & Long, VA 1999, 'Diagnosis and treatment of complicated tubercular meningitis', Pharmacotherapy, vol. 19, no. 10, pp. 1167-1172. https://doi.org/10.1592/phco.19.15.1167.30575
Kelly, Julia J. ; Horowitz, Edward A. ; Destache, Christopher J. ; Fruin, Alan H. ; Long, Vicki A. / Diagnosis and treatment of complicated tubercular meningitis. In: Pharmacotherapy. 1999 ; Vol. 19, No. 10. pp. 1167-1172.
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