Dietary supplement interactions with antiretrovirals: a systematic review

Mohamed A. Jalloh, Philip J. Gregory, Darren Hein, Zara Risoldi Cochrane, Aleah Rodriguez

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Many patients who take antiretroviral drugs also take alternative therapies including dietary supplements. Some drug–supplement combinations may result in clinically meaningful interactions. We aimed to investigate the evidence for dietary supplement interactions with antiretrovirals. A systematic review was conducted using multiple resources including PubMed, Natural Medicine Comprehensive Database, The Review of Natural Products, and Google Scholar. All human studies or case reports evaluating an interaction between a dietary supplement and an antiretroviral were selected for inclusion. Twenty-eight pharmacokinetic studies and case-series/case reports were selected for inclusion. Calcium carbonate, ferrous fumarate, some forms of ginkgo, some forms of garlic, some forms of milk thistle, St. John's wort, vitamin C, zinc sulfate, and multivitamins were all found to significantly decrease the levels of selected antiretrovirals and should be avoided in patients taking these antiretrovirals. Cat's claw and evening primrose oil were found to significantly increase the levels of antiretrovirals and patients should be monitored for adverse effects while taking these dietary supplements with antiretrovirals. This systematic review shows the importance of screening all human immunodeficiency virus patients for dietary supplement use to prevent treatment failure or adverse effects related to an interaction.

Original languageEnglish (US)
Pages (from-to)4-15
Number of pages12
JournalInternational Journal of STD and AIDS
Volume28
Issue number1
DOIs
StatePublished - 2015

Fingerprint

Dietary Supplements
Cat's Claw
Milk Thistle
Zinc Sulfate
Hypericum
Ginkgo biloba
Garlic
Calcium Carbonate
Complementary Therapies
Biological Products
Treatment Failure
PubMed
Ascorbic Acid
Pharmacokinetics
Medicine
HIV
Databases
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Public Health, Environmental and Occupational Health
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Jalloh, M. A., Gregory, P. J., Hein, D., Risoldi Cochrane, Z., & Rodriguez, A. (2015). Dietary supplement interactions with antiretrovirals: a systematic review. International Journal of STD and AIDS, 28(1), 4-15. https://doi.org/10.1177/0956462416671087

Dietary supplement interactions with antiretrovirals : a systematic review. / Jalloh, Mohamed A.; Gregory, Philip J.; Hein, Darren; Risoldi Cochrane, Zara; Rodriguez, Aleah.

In: International Journal of STD and AIDS, Vol. 28, No. 1, 2015, p. 4-15.

Research output: Contribution to journalReview article

Jalloh, MA, Gregory, PJ, Hein, D, Risoldi Cochrane, Z & Rodriguez, A 2015, 'Dietary supplement interactions with antiretrovirals: a systematic review', International Journal of STD and AIDS, vol. 28, no. 1, pp. 4-15. https://doi.org/10.1177/0956462416671087
Jalloh, Mohamed A. ; Gregory, Philip J. ; Hein, Darren ; Risoldi Cochrane, Zara ; Rodriguez, Aleah. / Dietary supplement interactions with antiretrovirals : a systematic review. In: International Journal of STD and AIDS. 2015 ; Vol. 28, No. 1. pp. 4-15.
@article{5245fcf4b3724e8da1de9c417b3d4d1b,
title = "Dietary supplement interactions with antiretrovirals: a systematic review",
abstract = "Many patients who take antiretroviral drugs also take alternative therapies including dietary supplements. Some drug–supplement combinations may result in clinically meaningful interactions. We aimed to investigate the evidence for dietary supplement interactions with antiretrovirals. A systematic review was conducted using multiple resources including PubMed, Natural Medicine Comprehensive Database, The Review of Natural Products, and Google Scholar. All human studies or case reports evaluating an interaction between a dietary supplement and an antiretroviral were selected for inclusion. Twenty-eight pharmacokinetic studies and case-series/case reports were selected for inclusion. Calcium carbonate, ferrous fumarate, some forms of ginkgo, some forms of garlic, some forms of milk thistle, St. John's wort, vitamin C, zinc sulfate, and multivitamins were all found to significantly decrease the levels of selected antiretrovirals and should be avoided in patients taking these antiretrovirals. Cat's claw and evening primrose oil were found to significantly increase the levels of antiretrovirals and patients should be monitored for adverse effects while taking these dietary supplements with antiretrovirals. This systematic review shows the importance of screening all human immunodeficiency virus patients for dietary supplement use to prevent treatment failure or adverse effects related to an interaction.",
author = "Jalloh, {Mohamed A.} and Gregory, {Philip J.} and Darren Hein and {Risoldi Cochrane}, Zara and Aleah Rodriguez",
year = "2015",
doi = "10.1177/0956462416671087",
language = "English (US)",
volume = "28",
pages = "4--15",
journal = "International Journal of STD and AIDS",
issn = "0956-4624",
publisher = "SAGE Publications Ltd",
number = "1",

}

TY - JOUR

T1 - Dietary supplement interactions with antiretrovirals

T2 - a systematic review

AU - Jalloh, Mohamed A.

AU - Gregory, Philip J.

AU - Hein, Darren

AU - Risoldi Cochrane, Zara

AU - Rodriguez, Aleah

PY - 2015

Y1 - 2015

N2 - Many patients who take antiretroviral drugs also take alternative therapies including dietary supplements. Some drug–supplement combinations may result in clinically meaningful interactions. We aimed to investigate the evidence for dietary supplement interactions with antiretrovirals. A systematic review was conducted using multiple resources including PubMed, Natural Medicine Comprehensive Database, The Review of Natural Products, and Google Scholar. All human studies or case reports evaluating an interaction between a dietary supplement and an antiretroviral were selected for inclusion. Twenty-eight pharmacokinetic studies and case-series/case reports were selected for inclusion. Calcium carbonate, ferrous fumarate, some forms of ginkgo, some forms of garlic, some forms of milk thistle, St. John's wort, vitamin C, zinc sulfate, and multivitamins were all found to significantly decrease the levels of selected antiretrovirals and should be avoided in patients taking these antiretrovirals. Cat's claw and evening primrose oil were found to significantly increase the levels of antiretrovirals and patients should be monitored for adverse effects while taking these dietary supplements with antiretrovirals. This systematic review shows the importance of screening all human immunodeficiency virus patients for dietary supplement use to prevent treatment failure or adverse effects related to an interaction.

AB - Many patients who take antiretroviral drugs also take alternative therapies including dietary supplements. Some drug–supplement combinations may result in clinically meaningful interactions. We aimed to investigate the evidence for dietary supplement interactions with antiretrovirals. A systematic review was conducted using multiple resources including PubMed, Natural Medicine Comprehensive Database, The Review of Natural Products, and Google Scholar. All human studies or case reports evaluating an interaction between a dietary supplement and an antiretroviral were selected for inclusion. Twenty-eight pharmacokinetic studies and case-series/case reports were selected for inclusion. Calcium carbonate, ferrous fumarate, some forms of ginkgo, some forms of garlic, some forms of milk thistle, St. John's wort, vitamin C, zinc sulfate, and multivitamins were all found to significantly decrease the levels of selected antiretrovirals and should be avoided in patients taking these antiretrovirals. Cat's claw and evening primrose oil were found to significantly increase the levels of antiretrovirals and patients should be monitored for adverse effects while taking these dietary supplements with antiretrovirals. This systematic review shows the importance of screening all human immunodeficiency virus patients for dietary supplement use to prevent treatment failure or adverse effects related to an interaction.

UR - http://www.scopus.com/inward/record.url?scp=85009936561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85009936561&partnerID=8YFLogxK

U2 - 10.1177/0956462416671087

DO - 10.1177/0956462416671087

M3 - Review article

C2 - 27655839

AN - SCOPUS:85009936561

VL - 28

SP - 4

EP - 15

JO - International Journal of STD and AIDS

JF - International Journal of STD and AIDS

SN - 0956-4624

IS - 1

ER -