Abstract
The spectrum of teratogenic and carcinogenic effects which can be exerted when the unborn child is exposed to diethylstilbestrol (DES) has been shown to be broad. Animal work indicates the need for vigilance as regards genetic susceptibility to DES sequelae. The emergence of third generation sequelae has been demonstrated in mice, and has been postulated to occur in humans. Given the emergent data establishing problems of infertility in men and women and of relatively late onset cancer, and the possibility that in utero exposure to DES may prime a variety of tissues to noxious environmental influences there is an urgent need for measures to provide just coverage for those harmed by the drug. The DES disaster also raises important ethical and reserch questions which demand attention.
| Original language | English |
|---|---|
| Pages (from-to) | 171-193 |
| Number of pages | 23 |
| Journal | International Journal of Risk and Safety in Medicine |
| Volume | 1 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1990 |
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All Science Journal Classification (ASJC) codes
- Medicine(all)
- Public Health, Environmental and Occupational Health
- Health Policy
Cite this
Diethylstilbestrol, teratogenesis, and carcinogenesis : Medical/legal implications of its long-term sequelae, including third generation effects. / Lynch, Henry T.; Quinn, Thomas; Severin, Matthew J.
In: International Journal of Risk and Safety in Medicine, Vol. 1, No. 3, 1990, p. 171-193.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Diethylstilbestrol, teratogenesis, and carcinogenesis
T2 - Medical/legal implications of its long-term sequelae, including third generation effects
AU - Lynch, Henry T.
AU - Quinn, Thomas
AU - Severin, Matthew J.
PY - 1990
Y1 - 1990
N2 - The spectrum of teratogenic and carcinogenic effects which can be exerted when the unborn child is exposed to diethylstilbestrol (DES) has been shown to be broad. Animal work indicates the need for vigilance as regards genetic susceptibility to DES sequelae. The emergence of third generation sequelae has been demonstrated in mice, and has been postulated to occur in humans. Given the emergent data establishing problems of infertility in men and women and of relatively late onset cancer, and the possibility that in utero exposure to DES may prime a variety of tissues to noxious environmental influences there is an urgent need for measures to provide just coverage for those harmed by the drug. The DES disaster also raises important ethical and reserch questions which demand attention.
AB - The spectrum of teratogenic and carcinogenic effects which can be exerted when the unborn child is exposed to diethylstilbestrol (DES) has been shown to be broad. Animal work indicates the need for vigilance as regards genetic susceptibility to DES sequelae. The emergence of third generation sequelae has been demonstrated in mice, and has been postulated to occur in humans. Given the emergent data establishing problems of infertility in men and women and of relatively late onset cancer, and the possibility that in utero exposure to DES may prime a variety of tissues to noxious environmental influences there is an urgent need for measures to provide just coverage for those harmed by the drug. The DES disaster also raises important ethical and reserch questions which demand attention.
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U2 - 10.3233/JRS-1990-1301
DO - 10.3233/JRS-1990-1301
M3 - Article
VL - 1
SP - 171
EP - 193
JO - International Journal of Risk and Safety in Medicine
JF - International Journal of Risk and Safety in Medicine
SN - 0924-6479
IS - 3
ER -