Differential actions of lamprey peptide methionine-tyrosine at Y1 and Y2 neuropeptide Y receptors

James E. Porter, Ambikaipakan Balasubramaniam, Peter W. Abel, J. Michael Conlon

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Peptide methionine-tyrosine (PMY), a peptide of the neuropeptide Y (NPY) superfamily isolated from the brain and intestine of the sea lamprey, had the same maximum effect but was 11-fold less potent than pig NPY in inhibiting field-stimulated contraction of the rat vas deferens, an effect mediated through the Y2 receptor. In contrast, PMY produced a 9-fold greater maximum effect but was 3-fold less potent than pig NPY in contracting the guinea pig mesenteric artery, an effect mediated through the Y1 receptor. Molecular modelling has suggested that the conformation of PMY is appreciably different from NPY only in the β-turn region of the molecule (residues 9-14). Our data suggest, therefore, that modifications in this region of NPY may useful in the design of receptor selective analogs.

Original languageEnglish (US)
Pages (from-to)489-493
Number of pages5
JournalRegulatory Peptides
Volume54
Issue number2-3
DOIs
StatePublished - Dec 15 1994

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Clinical Biochemistry
  • Cellular and Molecular Neuroscience

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