Differential effects of embryo transfer and maternal factors on anxiety-related behavior and numbers of neuropeptide Y (NPY) and parvalbumin (PARV) containing neurons in the amygdala of inbred C3H/HeN and DBA/2J mice

Claudia Rose, Herbert Schwegler, Joachim Hanke, Friedrich Wilhelm Röhl, Deniz M. Yilmazer-Hanke

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Abstract

The effects of reciprocal embryo transfers were studied on anxiety-related behavior of inbred C3H/HeN and DBA/2J mice on the elevated plus maze (EPM), and related to amygdaloid neuropeptide Y (NPY)- and parvalbumin (PARV)-immunoreactive neurons. Embryo transfer significantly reduced closed arm entries in in-stain-transferred C3H mice, and maternal factors influenced open arm entries only in interaction with genetic background and sex. In DBA/2J-mice, embryo transfer resulted in a reduced number of NPY-immunoreactive (NPY-ir) neurons, while PARV-immunoreactive (PARV-ir) cells were not affected. In C3H/HeN mice, however, in-strain embryo transfer only resulted in a reduction of the number of PARV-immunoreactive neurons. Maternal factors mainly induced changes in the number of NPY-ir neurons in the basolateral complex of the amygdala either directly or in interaction with genetic factors. In summary, in-strain embryo transfer had a minor effect on the behavior of C3H/HeN mice, and a differential influence on the numbers of amygdaloid NPY-ir and PARV-ir neurons of inbred C3H/HeN and DBA/2J mice. Maternal factors had a stronger impact on the numbers of NPY-ir neurons than PARV-ir neurons. The present results indicate that alterations in behavior and amygdala morphology induced by embryo transfer or maternal factors depend on the genetic background of the mouse strains used.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalBehavioural Brain Research
Volume173
Issue number1
DOIs
StatePublished - Oct 2 2006
Externally publishedYes

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Transfer Factor
Parvalbumins
Inbred DBA Mouse
Embryo Transfer
Neuropeptide Y
Amygdala
Anxiety
Mothers
Neurons
Inbred C3H Mouse
Coloring Agents

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

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Differential effects of embryo transfer and maternal factors on anxiety-related behavior and numbers of neuropeptide Y (NPY) and parvalbumin (PARV) containing neurons in the amygdala of inbred C3H/HeN and DBA/2J mice. / Rose, Claudia; Schwegler, Herbert; Hanke, Joachim; Röhl, Friedrich Wilhelm; Yilmazer-Hanke, Deniz M.

In: Behavioural Brain Research, Vol. 173, No. 1, 02.10.2006, p. 163-168.

Research output: Contribution to journalArticle

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