Abstract
Candida albicans exhibits greater susceptibility to inactivation by ultraviolet (uv) radiation if grown before or after irradiation at 37° C rather than 25° C. Caffeine, acriflavin or amino acid analogues potentiate inactivation during postirradiation growth at 37° C but have little effect at 25° C. In contrast to inactivation, mutation induction by uv is unaffected by pre- or postirradiation growth temperatures or by metabolic antagonists. These findings are not explicable in terms of possible effects of growth temperatures on known mechanisms for repair of uv damaged DNA. They are consistent, however, with a previous proposal that a temperature dependent mechanism for dark recovery exists in C. albicans which involves synthesis of protein essential for repair of lethal, non-genetic uv damage.
| Original language | English |
|---|---|
| Pages (from-to) | 189-198 |
| Number of pages | 10 |
| Journal | Archiv für Mikrobiologie |
| Volume | 67 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1969 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Microbiology
- Medicine(all)
Cite this
Differential effects of growth temperatures on inactivation and mutation of Candida albicans by ultraviolet radiation. / Sarachek, A.; Goering, Richard V.; Bish, J. T.
In: Archiv für Mikrobiologie, Vol. 67, No. 2, 06.1969, p. 189-198.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Differential effects of growth temperatures on inactivation and mutation of Candida albicans by ultraviolet radiation
AU - Sarachek, A.
AU - Goering, Richard V.
AU - Bish, J. T.
PY - 1969/6
Y1 - 1969/6
N2 - Candida albicans exhibits greater susceptibility to inactivation by ultraviolet (uv) radiation if grown before or after irradiation at 37° C rather than 25° C. Caffeine, acriflavin or amino acid analogues potentiate inactivation during postirradiation growth at 37° C but have little effect at 25° C. In contrast to inactivation, mutation induction by uv is unaffected by pre- or postirradiation growth temperatures or by metabolic antagonists. These findings are not explicable in terms of possible effects of growth temperatures on known mechanisms for repair of uv damaged DNA. They are consistent, however, with a previous proposal that a temperature dependent mechanism for dark recovery exists in C. albicans which involves synthesis of protein essential for repair of lethal, non-genetic uv damage.
AB - Candida albicans exhibits greater susceptibility to inactivation by ultraviolet (uv) radiation if grown before or after irradiation at 37° C rather than 25° C. Caffeine, acriflavin or amino acid analogues potentiate inactivation during postirradiation growth at 37° C but have little effect at 25° C. In contrast to inactivation, mutation induction by uv is unaffected by pre- or postirradiation growth temperatures or by metabolic antagonists. These findings are not explicable in terms of possible effects of growth temperatures on known mechanisms for repair of uv damaged DNA. They are consistent, however, with a previous proposal that a temperature dependent mechanism for dark recovery exists in C. albicans which involves synthesis of protein essential for repair of lethal, non-genetic uv damage.
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U2 - 10.1007/BF00409685
DO - 10.1007/BF00409685
M3 - Article
VL - 67
SP - 189
EP - 198
JO - Archiv für Mikrobiologie
JF - Archiv für Mikrobiologie
SN - 0302-8933
IS - 2
ER -