Distribution of methacholine inhalation challenge responses in a selected adult population

Durward M. Lang, Russell J. Hopp, Againdra K. Bewtra, Nicki M. Nair, Gavin D. Watt, Robert G. Townley

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

To determine bronchial reactivity patterns in adults, 211 subjects, 22 to 86 years of age, underwent a methacholine challenge in a Natural History of Asthma study. The diagnosis of asthma or nonasthmatic allergic diseases was based on a standardized respiratory questionnaire. Subjects were nonsmokers and had not had an infection for 1 month. Intradermal skin tests were done to a battery of common antigens. The methacholine challenge response was expressed as the area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units. Thirty-three subjects with asthma, 47 normal subjects from normal families (NF), 59 normal subjects from families with asthma (AF), 31 allergic subjects without asthma, 23 subjects with questionable asthma, and 18 subjects with prior asthma were studied. Overall, 50% of the subjects without asthma had a negative response to methacholine. There was a difference (p <0.02) in the distribution of log10 methacholine area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units responses in normal subjects from NFs compared to normal subjects from AFs. The allergic subjects from AF had a greater degree of bronchial reactivity compared to normal individuals from NF. The age of the normal subjects had an influence on the degree of bronchial reactivity. Methacholine challenge studies in adult patients need to be interpreted with age and family history in mind.

Original languageEnglish
Pages (from-to)533-540
Number of pages8
JournalJournal of Allergy and Clinical Immunology
Volume79
Issue number3
DOIs
StatePublished - 1987

Fingerprint

Methacholine Chloride
Inhalation
Asthma
Population
Intradermal Tests
Skin Tests
Antigens
Infection

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

Distribution of methacholine inhalation challenge responses in a selected adult population. / Lang, Durward M.; Hopp, Russell J.; Bewtra, Againdra K.; Nair, Nicki M.; Watt, Gavin D.; Townley, Robert G.

In: Journal of Allergy and Clinical Immunology, Vol. 79, No. 3, 1987, p. 533-540.

Research output: Contribution to journalArticle

Lang, Durward M. ; Hopp, Russell J. ; Bewtra, Againdra K. ; Nair, Nicki M. ; Watt, Gavin D. ; Townley, Robert G. / Distribution of methacholine inhalation challenge responses in a selected adult population. In: Journal of Allergy and Clinical Immunology. 1987 ; Vol. 79, No. 3. pp. 533-540.
@article{841acddc4d1742d4a586735dab4a3d0c,
title = "Distribution of methacholine inhalation challenge responses in a selected adult population",
abstract = "To determine bronchial reactivity patterns in adults, 211 subjects, 22 to 86 years of age, underwent a methacholine challenge in a Natural History of Asthma study. The diagnosis of asthma or nonasthmatic allergic diseases was based on a standardized respiratory questionnaire. Subjects were nonsmokers and had not had an infection for 1 month. Intradermal skin tests were done to a battery of common antigens. The methacholine challenge response was expressed as the area under the dose-response curve integrated to a 35{\%} fall in the FEV1 or 800 breath units. Thirty-three subjects with asthma, 47 normal subjects from normal families (NF), 59 normal subjects from families with asthma (AF), 31 allergic subjects without asthma, 23 subjects with questionable asthma, and 18 subjects with prior asthma were studied. Overall, 50{\%} of the subjects without asthma had a negative response to methacholine. There was a difference (p <0.02) in the distribution of log10 methacholine area under the dose-response curve integrated to a 35{\%} fall in the FEV1 or 800 breath units responses in normal subjects from NFs compared to normal subjects from AFs. The allergic subjects from AF had a greater degree of bronchial reactivity compared to normal individuals from NF. The age of the normal subjects had an influence on the degree of bronchial reactivity. Methacholine challenge studies in adult patients need to be interpreted with age and family history in mind.",
author = "Lang, {Durward M.} and Hopp, {Russell J.} and Bewtra, {Againdra K.} and Nair, {Nicki M.} and Watt, {Gavin D.} and Townley, {Robert G.}",
year = "1987",
doi = "10.1016/0091-6749(87)90372-1",
language = "English",
volume = "79",
pages = "533--540",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "3",

}

TY - JOUR

T1 - Distribution of methacholine inhalation challenge responses in a selected adult population

AU - Lang, Durward M.

AU - Hopp, Russell J.

AU - Bewtra, Againdra K.

AU - Nair, Nicki M.

AU - Watt, Gavin D.

AU - Townley, Robert G.

PY - 1987

Y1 - 1987

N2 - To determine bronchial reactivity patterns in adults, 211 subjects, 22 to 86 years of age, underwent a methacholine challenge in a Natural History of Asthma study. The diagnosis of asthma or nonasthmatic allergic diseases was based on a standardized respiratory questionnaire. Subjects were nonsmokers and had not had an infection for 1 month. Intradermal skin tests were done to a battery of common antigens. The methacholine challenge response was expressed as the area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units. Thirty-three subjects with asthma, 47 normal subjects from normal families (NF), 59 normal subjects from families with asthma (AF), 31 allergic subjects without asthma, 23 subjects with questionable asthma, and 18 subjects with prior asthma were studied. Overall, 50% of the subjects without asthma had a negative response to methacholine. There was a difference (p <0.02) in the distribution of log10 methacholine area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units responses in normal subjects from NFs compared to normal subjects from AFs. The allergic subjects from AF had a greater degree of bronchial reactivity compared to normal individuals from NF. The age of the normal subjects had an influence on the degree of bronchial reactivity. Methacholine challenge studies in adult patients need to be interpreted with age and family history in mind.

AB - To determine bronchial reactivity patterns in adults, 211 subjects, 22 to 86 years of age, underwent a methacholine challenge in a Natural History of Asthma study. The diagnosis of asthma or nonasthmatic allergic diseases was based on a standardized respiratory questionnaire. Subjects were nonsmokers and had not had an infection for 1 month. Intradermal skin tests were done to a battery of common antigens. The methacholine challenge response was expressed as the area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units. Thirty-three subjects with asthma, 47 normal subjects from normal families (NF), 59 normal subjects from families with asthma (AF), 31 allergic subjects without asthma, 23 subjects with questionable asthma, and 18 subjects with prior asthma were studied. Overall, 50% of the subjects without asthma had a negative response to methacholine. There was a difference (p <0.02) in the distribution of log10 methacholine area under the dose-response curve integrated to a 35% fall in the FEV1 or 800 breath units responses in normal subjects from NFs compared to normal subjects from AFs. The allergic subjects from AF had a greater degree of bronchial reactivity compared to normal individuals from NF. The age of the normal subjects had an influence on the degree of bronchial reactivity. Methacholine challenge studies in adult patients need to be interpreted with age and family history in mind.

UR - http://www.scopus.com/inward/record.url?scp=0023115607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023115607&partnerID=8YFLogxK

U2 - 10.1016/0091-6749(87)90372-1

DO - 10.1016/0091-6749(87)90372-1

M3 - Article

VL - 79

SP - 533

EP - 540

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 3

ER -