DNA methylation in breast and colorectal cancers

Anshu Agrawal, Richard F. Murphy, Devendra K. Agrawal

Research output: Contribution to journalReview article

98 Citations (Scopus)

Abstract

DNA methylation is one of several epigenetic changes observed in cells. Aberrant methylation of tumor suppressor genes, proto-oncogenes, and vital cell cycle genes has led many scientists to investigate the underlying cellular mechanisms of DNA methylation under normal and pathological conditions. Although DNA methylation is necessary for normal mammalian embryogenesis, both hypo- and hypermethylation of DNA are frequently observed in carcinogenesis and other pathological disorders. DNA hypermethylation silences the transcription of many tumor suppressor genes, resulting in immortalization of tumor cells. The reverse process, demethylation and restoration of normal functional expression of genes, is augmented by DNA methylation inhibitors. Recent studies suggest that DNA hypomethylation may also control gene expression and chromosomal stability. However, the roles of and relationship between hypomethylation and hypermethylation are not well understood. This review provides a brief overview of the mechanism of DNA methylation, its relationship to extrinsic stimulation including dietary intake and aging, and of abnormally methylated DNA in breast and colorectal cancers, which could be used as prognostic and diagnostic markers.

Original languageEnglish
Pages (from-to)711-721
Number of pages11
JournalModern Pathology
Volume20
Issue number7
DOIs
StatePublished - Jul 2007

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DNA Methylation
Colorectal Neoplasms
Breast Neoplasms
DNA
Tumor Suppressor Genes
Gene Expression
cdc Genes
Chromosomal Instability
Proto-Oncogenes
Epigenomics
Methylation
Embryonic Development
Carcinogenesis
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

DNA methylation in breast and colorectal cancers. / Agrawal, Anshu; Murphy, Richard F.; Agrawal, Devendra K.

In: Modern Pathology, Vol. 20, No. 7, 07.2007, p. 711-721.

Research output: Contribution to journalReview article

Agrawal, Anshu ; Murphy, Richard F. ; Agrawal, Devendra K. / DNA methylation in breast and colorectal cancers. In: Modern Pathology. 2007 ; Vol. 20, No. 7. pp. 711-721.
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