Does accepting pharmacokinetic recommendations impact hospitalization? A cost-benefit analysis

Christopher J. Destache, Sharon K. Meyer, Karen M. Rowley

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

In a prospective, randomized study, 110 adults receiving aminogly-cosides were randomized to follow-up by a clinical pharmacokinetic service (CPS). Of the 110 patients, 35 accepted pharmacokinetic recommendations less than 100% of the time. The two groups were similar in age, sex, height, APACHE II score, and initial creatinine clearance. A cost-to-charge ratio was used to derive direct costs of hospitalization and calculate cost-benefit. Patients whose physicians accepted pharmacokinetic recommendations 100% of the time had shorter hospitalizations (322.67 ± 270.28 h; CPS <100%, 699.54 ± 806.35; p = 0.001) and febrile periods (50.05 ± 79.38 h; CPS <100%, 120.00 ± 153.23; p = 0.002). Acceptance of CPS recommendations led to adequate peak levels. Acceptance of CPS recommendations led to lower direct costs (7,102.56 ± 9,898.19; CPS <100%, 19,629.94 ± 28,051.89; p <0.001). Calculated direct cost of the service was 85/patient.

Original languageEnglish
Pages (from-to)427-433
Number of pages7
JournalTherapeutic Drug Monitoring
Volume12
Issue number5
StatePublished - 1990

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Cost benefit analysis
Pharmacokinetics
Cost-Benefit Analysis
Hospitalization
Costs
Costs and Cost Analysis
Direct Service Costs
APACHE
Creatinine
Fever
Prospective Studies
Physicians

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Toxicology

Cite this

Does accepting pharmacokinetic recommendations impact hospitalization? A cost-benefit analysis. / Destache, Christopher J.; Meyer, Sharon K.; Rowley, Karen M.

In: Therapeutic Drug Monitoring, Vol. 12, No. 5, 1990, p. 427-433.

Research output: Contribution to journalArticle

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