Does integrin-mediated cell death confer tissue tropism in metastasis?

Jill M. Lahti, Tal Teitz, Dwayne G. Stupack

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

To develop metastatic capability, tumor cells must evolve the capacity to survive in novel microenvironments. Recently, we showed that metastasis of neuroblastoma cells is enhanced by loss of caspase-8, an event that occurs frequently in this malignancy. In poorly metastatic cells, unligated integrins were found to trigger activation of caspase-8, providing a selective pressure to promote its attenuation and thereby increased survival in foreign adhesive environments. Our findings suggest one mechanism by which the organotropism of metastastic cancer cells can arise.

Original languageEnglish (US)
Pages (from-to)5981-5984
Number of pages4
JournalCancer Research
Volume66
Issue number12
DOIs
StatePublished - Jun 15 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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