Abstract
Splenectomy is a recognized factor predisposing to the late complication of serious sepsis. The meningococcus has been listed as an important organism in postsplenectomy infection. A survey of the literature, however, revealed a total of only 13 documented case reports over a 31-year period, including ten pediatric cases. No documented cases of meningococcal sepsis in children following splenectomy for trauma were found. In an experimental mouse meningococcal infection model, the intraperitoneal LD50 was similar between normal and splenectomized mice (4×108 v 4×107 cfu, respectively; P=not significant). Bacteremic patterns were similar in both groups. Uniform survival was seen in normal and splenectomized mice after various intravenous challenge doses of meningococci up to 106 cfu. This was associated with efficient bacterial clearance in both groups. It appears unlikely that the defect resulting from splenectomy alone is an important predisposing factor in meningococcal sepsis.
| Original language | English |
|---|---|
| Pages (from-to) | 326-330 |
| Number of pages | 5 |
| Journal | Journal of Pediatric Surgery |
| Volume | 21 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1986 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Surgery
Cite this
Does splenectomy predispose to meningococcal sepsis? An experimental study and clinical review. / Loggie, Brian W.; John Hinchey, E.
In: Journal of Pediatric Surgery, Vol. 21, No. 4, 1986, p. 326-330.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Does splenectomy predispose to meningococcal sepsis? An experimental study and clinical review
AU - Loggie, Brian W.
AU - John Hinchey, E.
PY - 1986
Y1 - 1986
N2 - Splenectomy is a recognized factor predisposing to the late complication of serious sepsis. The meningococcus has been listed as an important organism in postsplenectomy infection. A survey of the literature, however, revealed a total of only 13 documented case reports over a 31-year period, including ten pediatric cases. No documented cases of meningococcal sepsis in children following splenectomy for trauma were found. In an experimental mouse meningococcal infection model, the intraperitoneal LD50 was similar between normal and splenectomized mice (4×108 v 4×107 cfu, respectively; P=not significant). Bacteremic patterns were similar in both groups. Uniform survival was seen in normal and splenectomized mice after various intravenous challenge doses of meningococci up to 106 cfu. This was associated with efficient bacterial clearance in both groups. It appears unlikely that the defect resulting from splenectomy alone is an important predisposing factor in meningococcal sepsis.
AB - Splenectomy is a recognized factor predisposing to the late complication of serious sepsis. The meningococcus has been listed as an important organism in postsplenectomy infection. A survey of the literature, however, revealed a total of only 13 documented case reports over a 31-year period, including ten pediatric cases. No documented cases of meningococcal sepsis in children following splenectomy for trauma were found. In an experimental mouse meningococcal infection model, the intraperitoneal LD50 was similar between normal and splenectomized mice (4×108 v 4×107 cfu, respectively; P=not significant). Bacteremic patterns were similar in both groups. Uniform survival was seen in normal and splenectomized mice after various intravenous challenge doses of meningococci up to 106 cfu. This was associated with efficient bacterial clearance in both groups. It appears unlikely that the defect resulting from splenectomy alone is an important predisposing factor in meningococcal sepsis.
UR - http://www.scopus.com/inward/record.url?scp=0022633989&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022633989&partnerID=8YFLogxK
U2 - 10.1016/S0022-3468(86)80195-6
DO - 10.1016/S0022-3468(86)80195-6
M3 - Article
C2 - 3701550
AN - SCOPUS:0022633989
VL - 21
SP - 326
EP - 330
JO - Journal of Pediatric Surgery
JF - Journal of Pediatric Surgery
SN - 0022-3468
IS - 4
ER -