Does splenectomy predispose to meningococcal sepsis? An experimental study and clinical review

Brian W. Loggie, E. John Hinchey

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Splenectomy is a recognized factor predisposing to the late complication of serious sepsis. The meningococcus has been listed as an important organism in postsplenectomy infection. A survey of the literature, however, revealed a total of only 13 documented case reports over a 31-year period, including ten pediatric cases. No documented cases of meningococcal sepsis in children following splenectomy for trauma were found. In an experimental mouse meningococcal infection model, the intraperitoneal LD50 was similar between normal and splenectomized mice (4×108 v 4×107 cfu, respectively; P=not significant). Bacteremic patterns were similar in both groups. Uniform survival was seen in normal and splenectomized mice after various intravenous challenge doses of meningococci up to 106 cfu. This was associated with efficient bacterial clearance in both groups. It appears unlikely that the defect resulting from splenectomy alone is an important predisposing factor in meningococcal sepsis.

Original languageEnglish
Pages (from-to)326-330
Number of pages5
JournalJournal of Pediatric Surgery
Volume21
Issue number4
DOIs
StatePublished - 1986
Externally publishedYes

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Splenectomy
Sepsis
Neisseria meningitidis
Causality
Meningococcal Infections
Lethal Dose 50
Pediatrics
Wounds and Injuries
Infection
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

Does splenectomy predispose to meningococcal sepsis? An experimental study and clinical review. / Loggie, Brian W.; John Hinchey, E.

In: Journal of Pediatric Surgery, Vol. 21, No. 4, 1986, p. 326-330.

Research output: Contribution to journalArticle

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