Dominant Susceptibility Effect on the Murine Corneal Response to Pseudomonas aeruginosa

Kirk Beisel, L. D. Hazlett, R. S. Berk

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Natural host resistance to Pseudomonas aeruginosa corneal infection is regulated by two complementing dominant genes PsCR1 and PsCR2 (RS Berk, MA Leon, LD Hazlett. Infect Immun 26:1221-1223, 1979). In this study we have demonstrated a third dominant gene, which determines susceptibility to P. aeruginosa-induced eye damage. This gene was designated as PsCS. The F1 progeny from matings between the resistant DBA/2J strain and the susceptible strain C57BL/6J and C3H/HeJ displayed the susceptibility phenotype. Backcross and F2 studies using the C3H/HeJ and DBA/2J strains suggested the presence of two linked PsCS loci.

Original languageEnglish
Pages (from-to)488-491
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume172
Issue number4
DOIs
StatePublished - 1983
Externally publishedYes

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Dominant Genes
Pseudomonas aeruginosa
Genes
Innate Immunity
Phenotype
Infection

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Dominant Susceptibility Effect on the Murine Corneal Response to Pseudomonas aeruginosa. / Beisel, Kirk; Hazlett, L. D.; Berk, R. S.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 172, No. 4, 1983, p. 488-491.

Research output: Contribution to journalArticle

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