Abstract
Natural host resistance to Pseudomonas aeruginosa corneal infection is regulated by two complementing dominant genes PsCR1 and PsCR2 (RS Berk, MA Leon, LD Hazlett. Infect Immun 26:1221-1223, 1979). In this study we have demonstrated a third dominant gene, which determines susceptibility to P. aeruginosa-induced eye damage. This gene was designated as PsCS. The F1 progeny from matings between the resistant DBA/2J strain and the susceptible strain C57BL/6J and C3H/HeJ displayed the susceptibility phenotype. Backcross and F2 studies using the C3H/HeJ and DBA/2J strains suggested the presence of two linked PsCS loci.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 488-491 |
| Number of pages | 4 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 172 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1983 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
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Cite this
Beisel, K. W., Hazlett, L. D., & Berk, R. S. (1983). Dominant Susceptibility Effect on the Murine Corneal Response to Pseudomonas aeruginosa. Proceedings of the Society for Experimental Biology and Medicine, 172(4), 488-491. https://doi.org/10.3181/00379727-172-41592