Dominant Susceptibility Effect on the Murine Corneal Response to Pseudomonas aeruginosa

K. W. Beisel; L. D. Hazlett; R. S. Berk

doi:10.3181/00379727-172-41592

Dominant Susceptibility Effect on the Murine Corneal Response to Pseudomonas aeruginosa

K. W. Beisel, L. D. Hazlett, R. S. Berk

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28 Scopus citations

Abstract

Natural host resistance to Pseudomonas aeruginosa corneal infection is regulated by two complementing dominant genes PsCR1 and PsCR2 (RS Berk, MA Leon, LD Hazlett. Infect Immun 26:1221-1223, 1979). In this study we have demonstrated a third dominant gene, which determines susceptibility to P. aeruginosa-induced eye damage. This gene was designated as PsCS. The F₁ progeny from matings between the resistant DBA/2J strain and the susceptible strain C57BL/6J and C3H/HeJ displayed the susceptibility phenotype. Backcross and F₂ studies using the C3H/HeJ and DBA/2J strains suggested the presence of two linked PsCS loci.

Original language	English (US)
Pages (from-to)	488-491
Number of pages	4
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	172
Issue number	4
DOIs	https://doi.org/10.3181/00379727-172-41592
State	Published - Apr 1983
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)

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abstract = "Natural host resistance to Pseudomonas aeruginosa corneal infection is regulated by two complementing dominant genes PsCR1 and PsCR2 (RS Berk, MA Leon, LD Hazlett. Infect Immun 26:1221-1223, 1979). In this study we have demonstrated a third dominant gene, which determines susceptibility to P. aeruginosa-induced eye damage. This gene was designated as PsCS. The F1 progeny from matings between the resistant DBA/2J strain and the susceptible strain C57BL/6J and C3H/HeJ displayed the susceptibility phenotype. Backcross and F2 studies using the C3H/HeJ and DBA/2J strains suggested the presence of two linked PsCS loci.",

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AB - Natural host resistance to Pseudomonas aeruginosa corneal infection is regulated by two complementing dominant genes PsCR1 and PsCR2 (RS Berk, MA Leon, LD Hazlett. Infect Immun 26:1221-1223, 1979). In this study we have demonstrated a third dominant gene, which determines susceptibility to P. aeruginosa-induced eye damage. This gene was designated as PsCS. The F1 progeny from matings between the resistant DBA/2J strain and the susceptible strain C57BL/6J and C3H/HeJ displayed the susceptibility phenotype. Backcross and F2 studies using the C3H/HeJ and DBA/2J strains suggested the presence of two linked PsCS loci.

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Dominant Susceptibility Effect on the Murine Corneal Response to Pseudomonas aeruginosa

Abstract

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