Double-blind, randomized, placebo-controlled evaluation of atropine to prevent vasovagal reaction during removal of femoral arterial sheaths

Bhola N. Rama; Syed M. Mohiuddin; Aryan N. Mooss; Anil K. Khemani; Kay L. Ryschon; B. Daniel Lucas; Daniel E. Hilleman

Double-blind, randomized, placebo-controlled evaluation of atropine to prevent vasovagal reaction during removal of femoral arterial sheaths

Bhola N. Rama, Syed M. Mohiuddin, Aryan N. Mooss, Anil K. Khemani, Kay L. Ryschon, B. Daniel Lucas, Daniel E. Hilleman

Research output: Contribution to journal › Article › peer-review

Abstract

Study Objective. To evaluate the efficacy and safety of atropine in preventing vasovagal reactions (VVRs) during removal of femoral arterial sheaths after diagnostic left heart catheterization. Design. Prospective, double-blind, randomized, placebo-controlled study. Setting. University- affiliated, 450-bed teaching hospital. Patients. One hundred sixty-five patients undergoing left heart catheterization. Interventions. Eighty-eight patients were assigned to receive atropine 0.5 mg intravenously and 77 received placebo 5 minutes before sheath removal. Measurements and Main Results. The frequency of VVRs was significantly reduced in the atropine group compared with the placebo group, 2.3% and 10.4%, respectively (overall relative risk in the atropine group 0.22, 95% CI 0.12-0.41, p=0.03). Significant decreases in systolic (35.2 ± 5.8 mm Hg, p

Original language	English (US)
Pages (from-to)	867-873
Number of pages	7
Journal	Pharmacotherapy
Volume	17
Issue number	5 I
State	Published - Sep 1997

All Science Journal Classification (ASJC) codes

Pharmacology (medical)

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Double-blind, randomized, placebo-controlled evaluation of atropine to prevent vasovagal reaction during removal of femoral arterial sheaths. / Rama, Bhola N.; Mohiuddin, Syed M.; Mooss, Aryan N.; Khemani, Anil K.; Ryschon, Kay L.; Lucas, B. Daniel; Hilleman, Daniel E.

In: Pharmacotherapy, Vol. 17, No. 5 I, 09.1997, p. 867-873.

Research output: Contribution to journal › Article › peer-review

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title = "Double-blind, randomized, placebo-controlled evaluation of atropine to prevent vasovagal reaction during removal of femoral arterial sheaths",

abstract = "Study Objective. To evaluate the efficacy and safety of atropine in preventing vasovagal reactions (VVRs) during removal of femoral arterial sheaths after diagnostic left heart catheterization. Design. Prospective, double-blind, randomized, placebo-controlled study. Setting. University- affiliated, 450-bed teaching hospital. Patients. One hundred sixty-five patients undergoing left heart catheterization. Interventions. Eighty-eight patients were assigned to receive atropine 0.5 mg intravenously and 77 received placebo 5 minutes before sheath removal. Measurements and Main Results. The frequency of VVRs was significantly reduced in the atropine group compared with the placebo group, 2.3% and 10.4%, respectively (overall relative risk in the atropine group 0.22, 95% CI 0.12-0.41, p=0.03). Significant decreases in systolic (35.2 ± 5.8 mm Hg, p",

author = "Rama, {Bhola N.} and Mohiuddin, {Syed M.} and Mooss, {Aryan N.} and Khemani, {Anil K.} and Ryschon, {Kay L.} and Lucas, {B. Daniel} and Hilleman, {Daniel E.}",

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T1 - Double-blind, randomized, placebo-controlled evaluation of atropine to prevent vasovagal reaction during removal of femoral arterial sheaths

AU - Rama, Bhola N.

AU - Mohiuddin, Syed M.

AU - Mooss, Aryan N.

AU - Khemani, Anil K.

AU - Ryschon, Kay L.

AU - Lucas, B. Daniel

AU - Hilleman, Daniel E.

PY - 1997/9

Y1 - 1997/9

N2 - Study Objective. To evaluate the efficacy and safety of atropine in preventing vasovagal reactions (VVRs) during removal of femoral arterial sheaths after diagnostic left heart catheterization. Design. Prospective, double-blind, randomized, placebo-controlled study. Setting. University- affiliated, 450-bed teaching hospital. Patients. One hundred sixty-five patients undergoing left heart catheterization. Interventions. Eighty-eight patients were assigned to receive atropine 0.5 mg intravenously and 77 received placebo 5 minutes before sheath removal. Measurements and Main Results. The frequency of VVRs was significantly reduced in the atropine group compared with the placebo group, 2.3% and 10.4%, respectively (overall relative risk in the atropine group 0.22, 95% CI 0.12-0.41, p=0.03). Significant decreases in systolic (35.2 ± 5.8 mm Hg, p

AB - Study Objective. To evaluate the efficacy and safety of atropine in preventing vasovagal reactions (VVRs) during removal of femoral arterial sheaths after diagnostic left heart catheterization. Design. Prospective, double-blind, randomized, placebo-controlled study. Setting. University- affiliated, 450-bed teaching hospital. Patients. One hundred sixty-five patients undergoing left heart catheterization. Interventions. Eighty-eight patients were assigned to receive atropine 0.5 mg intravenously and 77 received placebo 5 minutes before sheath removal. Measurements and Main Results. The frequency of VVRs was significantly reduced in the atropine group compared with the placebo group, 2.3% and 10.4%, respectively (overall relative risk in the atropine group 0.22, 95% CI 0.12-0.41, p=0.03). Significant decreases in systolic (35.2 ± 5.8 mm Hg, p

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