Abstract
Study Objective. To evaluate the efficacy and safety of atropine in preventing vasovagal reactions (VVRs) during removal of femoral arterial sheaths after diagnostic left heart catheterization. Design. Prospective, double-blind, randomized, placebo-controlled study. Setting. University- affiliated, 450-bed teaching hospital. Patients. One hundred sixty-five patients undergoing left heart catheterization. Interventions. Eighty-eight patients were assigned to receive atropine 0.5 mg intravenously and 77 received placebo 5 minutes before sheath removal. Measurements and Main Results. The frequency of VVRs was significantly reduced in the atropine group compared with the placebo group, 2.3% and 10.4%, respectively (overall relative risk in the atropine group 0.22, 95% CI 0.12-0.41, p=0.03). Significant decreases in systolic (35.2 ± 5.8 mm Hg, p
| Original language | English |
|---|---|
| Pages (from-to) | 867-873 |
| Number of pages | 7 |
| Journal | Pharmacotherapy |
| Volume | 17 |
| Issue number | 5 I |
| State | Published - Sep 1997 |
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All Science Journal Classification (ASJC) codes
- Pharmacology (medical)
- Pharmacology, Toxicology and Pharmaceutics(all)
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Double-blind, randomized, placebo-controlled evaluation of atropine to prevent vasovagal reaction during removal of femoral arterial sheaths. / Rama, Bhola N.; Mohiuddin, Syed M.; Mooss, Aryan N.; Khemani, Anil K.; Ryschon, Kay L.; Lucas, B. Daniel; Hilleman, Daniel E.
In: Pharmacotherapy, Vol. 17, No. 5 I, 09.1997, p. 867-873.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Double-blind, randomized, placebo-controlled evaluation of atropine to prevent vasovagal reaction during removal of femoral arterial sheaths
AU - Rama, Bhola N.
AU - Mohiuddin, Syed M.
AU - Mooss, Aryan N.
AU - Khemani, Anil K.
AU - Ryschon, Kay L.
AU - Lucas, B. Daniel
AU - Hilleman, Daniel E.
PY - 1997/9
Y1 - 1997/9
N2 - Study Objective. To evaluate the efficacy and safety of atropine in preventing vasovagal reactions (VVRs) during removal of femoral arterial sheaths after diagnostic left heart catheterization. Design. Prospective, double-blind, randomized, placebo-controlled study. Setting. University- affiliated, 450-bed teaching hospital. Patients. One hundred sixty-five patients undergoing left heart catheterization. Interventions. Eighty-eight patients were assigned to receive atropine 0.5 mg intravenously and 77 received placebo 5 minutes before sheath removal. Measurements and Main Results. The frequency of VVRs was significantly reduced in the atropine group compared with the placebo group, 2.3% and 10.4%, respectively (overall relative risk in the atropine group 0.22, 95% CI 0.12-0.41, p=0.03). Significant decreases in systolic (35.2 ± 5.8 mm Hg, p
AB - Study Objective. To evaluate the efficacy and safety of atropine in preventing vasovagal reactions (VVRs) during removal of femoral arterial sheaths after diagnostic left heart catheterization. Design. Prospective, double-blind, randomized, placebo-controlled study. Setting. University- affiliated, 450-bed teaching hospital. Patients. One hundred sixty-five patients undergoing left heart catheterization. Interventions. Eighty-eight patients were assigned to receive atropine 0.5 mg intravenously and 77 received placebo 5 minutes before sheath removal. Measurements and Main Results. The frequency of VVRs was significantly reduced in the atropine group compared with the placebo group, 2.3% and 10.4%, respectively (overall relative risk in the atropine group 0.22, 95% CI 0.12-0.41, p=0.03). Significant decreases in systolic (35.2 ± 5.8 mm Hg, p
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M3 - Article
VL - 17
SP - 867
EP - 873
JO - Pharmacotherapy
JF - Pharmacotherapy
SN - 0277-0008
IS - 5 I
ER -