Duration and specificity of sodium cromolyn on allergen inhalation challenges in asthmatics

Betty M. Kolotkin, Chong Kwan Lee, Robert G. Townley

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

In order to elucidate the mechanism of sodium cromolyn (Intal)* 1 > 20 per cent following allergen inhalation challenge were used in this experiment. Twelve patients were given 40 mg. disodium cromoglycate (DSCG) and then challenged on different days with allergen aerosol at 30 minutes, 5 hours, and 24 hours post-DSCG inhalation. Ten patients received one allergen 30 minutes post-DSCG and were challenged with the same or a dissimilar allergen 5 hours later. Protection against allergen-induced bronchoconstriction was significant at 30 minutes and 5 hours (p <0.001), but not at 24 hours. Bronchial protection with DSCG occurred during sequential allergen challenge using the same but not dissimilar allergens. DSCG protected against delayed reactions following allergen challenge, (p <0.01). The protection against the same allergen given twice, but not against a different allergen at 5 hours, suggests a mechanism of action of specific desensitization of the bronchial mast cells.

Original languageEnglish
Pages (from-to)288-297
Number of pages10
JournalJournal of Allergy and Clinical Immunology
Volume53
Issue number5
DOIs
StatePublished - 1974

Fingerprint

Cromolyn Sodium
Allergens
Inhalation
Bronchoconstriction
Aerosols
Mast Cells

All Science Journal Classification (ASJC) codes

  • Immunology
  • Immunology and Allergy

Cite this

Duration and specificity of sodium cromolyn on allergen inhalation challenges in asthmatics. / Kolotkin, Betty M.; Lee, Chong Kwan; Townley, Robert G.

In: Journal of Allergy and Clinical Immunology, Vol. 53, No. 5, 1974, p. 288-297.

Research output: Contribution to journalArticle

Kolotkin, Betty M. ; Lee, Chong Kwan ; Townley, Robert G. / Duration and specificity of sodium cromolyn on allergen inhalation challenges in asthmatics. In: Journal of Allergy and Clinical Immunology. 1974 ; Vol. 53, No. 5. pp. 288-297.
@article{a3bd9b706a374474b1ff486197632e41,
title = "Duration and specificity of sodium cromolyn on allergen inhalation challenges in asthmatics",
abstract = "In order to elucidate the mechanism of sodium cromolyn (Intal)* 1 > 20 per cent following allergen inhalation challenge were used in this experiment. Twelve patients were given 40 mg. disodium cromoglycate (DSCG) and then challenged on different days with allergen aerosol at 30 minutes, 5 hours, and 24 hours post-DSCG inhalation. Ten patients received one allergen 30 minutes post-DSCG and were challenged with the same or a dissimilar allergen 5 hours later. Protection against allergen-induced bronchoconstriction was significant at 30 minutes and 5 hours (p <0.001), but not at 24 hours. Bronchial protection with DSCG occurred during sequential allergen challenge using the same but not dissimilar allergens. DSCG protected against delayed reactions following allergen challenge, (p <0.01). The protection against the same allergen given twice, but not against a different allergen at 5 hours, suggests a mechanism of action of specific desensitization of the bronchial mast cells.",
author = "Kolotkin, {Betty M.} and Lee, {Chong Kwan} and Townley, {Robert G.}",
year = "1974",
doi = "10.1016/0091-6749(74)90108-0",
language = "English",
volume = "53",
pages = "288--297",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Duration and specificity of sodium cromolyn on allergen inhalation challenges in asthmatics

AU - Kolotkin, Betty M.

AU - Lee, Chong Kwan

AU - Townley, Robert G.

PY - 1974

Y1 - 1974

N2 - In order to elucidate the mechanism of sodium cromolyn (Intal)* 1 > 20 per cent following allergen inhalation challenge were used in this experiment. Twelve patients were given 40 mg. disodium cromoglycate (DSCG) and then challenged on different days with allergen aerosol at 30 minutes, 5 hours, and 24 hours post-DSCG inhalation. Ten patients received one allergen 30 minutes post-DSCG and were challenged with the same or a dissimilar allergen 5 hours later. Protection against allergen-induced bronchoconstriction was significant at 30 minutes and 5 hours (p <0.001), but not at 24 hours. Bronchial protection with DSCG occurred during sequential allergen challenge using the same but not dissimilar allergens. DSCG protected against delayed reactions following allergen challenge, (p <0.01). The protection against the same allergen given twice, but not against a different allergen at 5 hours, suggests a mechanism of action of specific desensitization of the bronchial mast cells.

AB - In order to elucidate the mechanism of sodium cromolyn (Intal)* 1 > 20 per cent following allergen inhalation challenge were used in this experiment. Twelve patients were given 40 mg. disodium cromoglycate (DSCG) and then challenged on different days with allergen aerosol at 30 minutes, 5 hours, and 24 hours post-DSCG inhalation. Ten patients received one allergen 30 minutes post-DSCG and were challenged with the same or a dissimilar allergen 5 hours later. Protection against allergen-induced bronchoconstriction was significant at 30 minutes and 5 hours (p <0.001), but not at 24 hours. Bronchial protection with DSCG occurred during sequential allergen challenge using the same but not dissimilar allergens. DSCG protected against delayed reactions following allergen challenge, (p <0.01). The protection against the same allergen given twice, but not against a different allergen at 5 hours, suggests a mechanism of action of specific desensitization of the bronchial mast cells.

UR - http://www.scopus.com/inward/record.url?scp=0016164714&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0016164714&partnerID=8YFLogxK

U2 - 10.1016/0091-6749(74)90108-0

DO - 10.1016/0091-6749(74)90108-0

M3 - Article

VL - 53

SP - 288

EP - 297

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -