Early Age of Onset in Familial Breast Cancer: Genetic and Cancer Control Implications

Henry T. Lynch, Hoda Guirgis, Frank Brodkey, Kathleen Maloney, Patrick M. Lynch, Laurie Rankin, Jane Lynch

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Although breast carcinoma is the most frequently occurring cancer in American women and has been the subject of extensive epidemiologic investigation, little attention has been devoted to use of risk-factor information in its control. Six of our 52 breast-cancer-prone families have at least one woman who has manifested breast cancer at age 30 years or earlier. One such family had two women with breast cancer before age 30, and at least ten others affected by age 50. Transmission of this lesion was consistent with autosomal-dominant mode of inheritance. Ages of onset indicated a notably early peak, in contrast with the expected pre- and post-menopausal peaks in findings of the New York State Tumor Registry and others. Genetic and epidemiologic information should be utilized to control breast cancer in certain families.

Original languageEnglish (US)
Pages (from-to)126-131
Number of pages6
JournalArchives of Surgery
Volume111
Issue number2
DOIs
StatePublished - Feb 1976

All Science Journal Classification (ASJC) codes

  • Surgery

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    Lynch, H. T., Guirgis, H., Brodkey, F., Maloney, K., Lynch, P. M., Rankin, L., & Lynch, J. (1976). Early Age of Onset in Familial Breast Cancer: Genetic and Cancer Control Implications. Archives of Surgery, 111(2), 126-131. https://doi.org/10.1001/archsurg.1976.01360200032006