Abstract
Context: Biochemical markers of bone turnover may reflect bone structure during anabolic treatment. Objective: The objective was to evaluate associations between changes in biochemical markers and structural and dynamic bone parameters during teriparatide treatment. Design: This study was a randomized, multicenter, double-blind, placebo-controlled fracture prevention trial, with 20-month median treatment duration for biopsy subset. Setting: The trial was conducted at 11 clinical study sites. Patients: Sixty-one postmenopausal women with osteoporosis who had paired transiliac biopsy specimens participated in the study. Interventions: Once-daily sc injections of either placebo or teriparatide (20 or 40 μg) were administered. Main outcome measures: The study measured: 1) serum and urinary biochemical markers of bone formation [bone alkaline phosphatase and procollagen I C-terminal propeptide (PICP)] and resorption (N-telopeptide and deoxypyridinoline); and 2) structural and dynamic analyses of bone biopsies, including two-dimensional (2D) histomorphometry and three-dimensional (3D) micro-computed tomography evaluations measured at baseline (n = 57) and 12 (n = 21) or 22 (n = 36) months. Results: U-N-telopeptide/creatinine and serum-PICP correlated with bone structure and dynamic indices at baseline, respectively. Changes in bone alkaline phosphatase at 1 month correlated with changes at 22 months in 2D wall thickness (r = 0.73; P = 0.001), trabecular bone volume (trabecular bone volume per total volume, BV/TV) (r = 0.58; P <0.05), marrow star volume (r = -0.51; P = 0.05); 3D trabecular thickness (r = 0.49; P <0.05), and BV/TV (r = 0.54; P <0.05). Changes in PICP at 1 month correlated with changes in wall thickness (r = 0.60; P = 0.01), and 2D BV/TV (r = 0.51; P <0.05) at 22 months. Changes in markers at 6 or 12 months were not associated with changes in structural or dynamic parameters. Conclusions: Early (1-month) changes in biochemical markers of bone formation, but not resorption, correlated with improvements in bone structure after 22 months of teriparatide therapy.
| Original language | English |
|---|---|
| Pages (from-to) | 3970-3977 |
| Number of pages | 8 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 90 |
| Issue number | 7 |
| DOIs | |
| State | Published - Jul 2005 |
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All Science Journal Classification (ASJC) codes
- Biochemistry
- Endocrinology, Diabetes and Metabolism
Cite this
Early changes in biochemical markers of bone formation correlate with improvements in bone structure during teriparatide therapy. / Dobnig, Harald; Sipos, Adrien; Jiang, Yebin; Fahrleitner-Pammer, Astrid; Ste-Marie, Louis Georges; Gallagher, John Christopher G.; Pavo, Imre; Wang, Jingyuan; Eriksen, Erik F.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 90, No. 7, 07.2005, p. 3970-3977.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early changes in biochemical markers of bone formation correlate with improvements in bone structure during teriparatide therapy
AU - Dobnig, Harald
AU - Sipos, Adrien
AU - Jiang, Yebin
AU - Fahrleitner-Pammer, Astrid
AU - Ste-Marie, Louis Georges
AU - Gallagher, John Christopher G.
AU - Pavo, Imre
AU - Wang, Jingyuan
AU - Eriksen, Erik F.
PY - 2005/7
Y1 - 2005/7
N2 - Context: Biochemical markers of bone turnover may reflect bone structure during anabolic treatment. Objective: The objective was to evaluate associations between changes in biochemical markers and structural and dynamic bone parameters during teriparatide treatment. Design: This study was a randomized, multicenter, double-blind, placebo-controlled fracture prevention trial, with 20-month median treatment duration for biopsy subset. Setting: The trial was conducted at 11 clinical study sites. Patients: Sixty-one postmenopausal women with osteoporosis who had paired transiliac biopsy specimens participated in the study. Interventions: Once-daily sc injections of either placebo or teriparatide (20 or 40 μg) were administered. Main outcome measures: The study measured: 1) serum and urinary biochemical markers of bone formation [bone alkaline phosphatase and procollagen I C-terminal propeptide (PICP)] and resorption (N-telopeptide and deoxypyridinoline); and 2) structural and dynamic analyses of bone biopsies, including two-dimensional (2D) histomorphometry and three-dimensional (3D) micro-computed tomography evaluations measured at baseline (n = 57) and 12 (n = 21) or 22 (n = 36) months. Results: U-N-telopeptide/creatinine and serum-PICP correlated with bone structure and dynamic indices at baseline, respectively. Changes in bone alkaline phosphatase at 1 month correlated with changes at 22 months in 2D wall thickness (r = 0.73; P = 0.001), trabecular bone volume (trabecular bone volume per total volume, BV/TV) (r = 0.58; P <0.05), marrow star volume (r = -0.51; P = 0.05); 3D trabecular thickness (r = 0.49; P <0.05), and BV/TV (r = 0.54; P <0.05). Changes in PICP at 1 month correlated with changes in wall thickness (r = 0.60; P = 0.01), and 2D BV/TV (r = 0.51; P <0.05) at 22 months. Changes in markers at 6 or 12 months were not associated with changes in structural or dynamic parameters. Conclusions: Early (1-month) changes in biochemical markers of bone formation, but not resorption, correlated with improvements in bone structure after 22 months of teriparatide therapy.
AB - Context: Biochemical markers of bone turnover may reflect bone structure during anabolic treatment. Objective: The objective was to evaluate associations between changes in biochemical markers and structural and dynamic bone parameters during teriparatide treatment. Design: This study was a randomized, multicenter, double-blind, placebo-controlled fracture prevention trial, with 20-month median treatment duration for biopsy subset. Setting: The trial was conducted at 11 clinical study sites. Patients: Sixty-one postmenopausal women with osteoporosis who had paired transiliac biopsy specimens participated in the study. Interventions: Once-daily sc injections of either placebo or teriparatide (20 or 40 μg) were administered. Main outcome measures: The study measured: 1) serum and urinary biochemical markers of bone formation [bone alkaline phosphatase and procollagen I C-terminal propeptide (PICP)] and resorption (N-telopeptide and deoxypyridinoline); and 2) structural and dynamic analyses of bone biopsies, including two-dimensional (2D) histomorphometry and three-dimensional (3D) micro-computed tomography evaluations measured at baseline (n = 57) and 12 (n = 21) or 22 (n = 36) months. Results: U-N-telopeptide/creatinine and serum-PICP correlated with bone structure and dynamic indices at baseline, respectively. Changes in bone alkaline phosphatase at 1 month correlated with changes at 22 months in 2D wall thickness (r = 0.73; P = 0.001), trabecular bone volume (trabecular bone volume per total volume, BV/TV) (r = 0.58; P <0.05), marrow star volume (r = -0.51; P = 0.05); 3D trabecular thickness (r = 0.49; P <0.05), and BV/TV (r = 0.54; P <0.05). Changes in PICP at 1 month correlated with changes in wall thickness (r = 0.60; P = 0.01), and 2D BV/TV (r = 0.51; P <0.05) at 22 months. Changes in markers at 6 or 12 months were not associated with changes in structural or dynamic parameters. Conclusions: Early (1-month) changes in biochemical markers of bone formation, but not resorption, correlated with improvements in bone structure after 22 months of teriparatide therapy.
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U2 - 10.1210/jc.2003-1703
DO - 10.1210/jc.2003-1703
M3 - Article
VL - 90
SP - 3970
EP - 3977
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 7
ER -