Early identification of DPAM in at-risk low-grade appendiceal mucinous neoplasm patients: A new approach to surveillance for peritoneal metastasis

Jason M. Foster, Richard L. Sleightholm, Steve Wahlmeier, Brian W. Loggie, Poonam K Sharma, Asish Patel

Research output: Contribution to journalArticle

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Abstract

Background: Disseminated peritoneal adenomucinosis (DPAM) patients often have a history of appendectomy with identification of an incidental mucinous neoplasm (low-grade appendiceal mucinous neoplasm (LAMN)). The rate of developing DPAM is not well established. Methods: Twenty-two patients with incidental LAMN were identified and monitored with cancer markers and CT every 4-6 months. Laparoscopy with peritoneal washing was performed in patients either in the event of radiographic disease or after 12 months in absence of radiographic disease. The rate of detecting peritoneal metastasis was determined for CT scan and laparoscopy. Results: Peritoneal metastasis was detected in 5 (23 %) patients. Occult disease was detected in four patients at laparoscopy without a detectable disease on CT scan. One patient developed radiographic progression at 6 months confirmed with laparoscopy. Four patients were treated with cytoreductive surgery (CRS)/HIPEC and one with CRS only. The 17 patients with negative laparoscopy remain disease free with a median follow-up of 50 months. Conclusions: The rate of peritoneal metastasis in incidental LAMN patients was 23 %. Laparoscopy was the primary screening tool identifying occult metastasis. The median PCI of 7 was low, and all the patients underwent R0/R1 resections. This study revealed 1 in every 4.4 patients with LAMN may develop PMP. Longer follow-up and further patient surveillance is warranted.

Original languageEnglish (US)
Article number243
JournalWorld Journal of Surgical Oncology
Volume14
Issue number1
DOIs
StatePublished - Sep 13 2016

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Appendiceal Neoplasms
Neoplasm Metastasis
Laparoscopy
Appendectomy

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Early identification of DPAM in at-risk low-grade appendiceal mucinous neoplasm patients : A new approach to surveillance for peritoneal metastasis. / Foster, Jason M.; Sleightholm, Richard L.; Wahlmeier, Steve; Loggie, Brian W.; Sharma, Poonam K; Patel, Asish.

In: World Journal of Surgical Oncology, Vol. 14, No. 1, 243, 13.09.2016.

Research output: Contribution to journalArticle

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abstract = "Background: Disseminated peritoneal adenomucinosis (DPAM) patients often have a history of appendectomy with identification of an incidental mucinous neoplasm (low-grade appendiceal mucinous neoplasm (LAMN)). The rate of developing DPAM is not well established. Methods: Twenty-two patients with incidental LAMN were identified and monitored with cancer markers and CT every 4-6 months. Laparoscopy with peritoneal washing was performed in patients either in the event of radiographic disease or after 12 months in absence of radiographic disease. The rate of detecting peritoneal metastasis was determined for CT scan and laparoscopy. Results: Peritoneal metastasis was detected in 5 (23 {\%}) patients. Occult disease was detected in four patients at laparoscopy without a detectable disease on CT scan. One patient developed radiographic progression at 6 months confirmed with laparoscopy. Four patients were treated with cytoreductive surgery (CRS)/HIPEC and one with CRS only. The 17 patients with negative laparoscopy remain disease free with a median follow-up of 50 months. Conclusions: The rate of peritoneal metastasis in incidental LAMN patients was 23 {\%}. Laparoscopy was the primary screening tool identifying occult metastasis. The median PCI of 7 was low, and all the patients underwent R0/R1 resections. This study revealed 1 in every 4.4 patients with LAMN may develop PMP. Longer follow-up and further patient surveillance is warranted.",
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