Early versus late surgical intervention or medical management for infective endocarditis: A systematic review and meta-analysis

Mahesh Anantha Narayanan, Toufik Mahfood Haddad, Andre C. Kalil, Arun Kanmanthareddy, Rakesh M. Suri, George Mansour, Christopher J. Destache, Janani Baskaran, Aryan N. Mooss, Tammy Wichman, Lee Morrow, Renuga Vivekanandan

Research output: Contribution to journalArticle

35 Scopus citations


Objective Infective endocarditis is associated with high morbidity and mortality and optimal timing for surgical intervention is unclear. We performed a systematic review and meta-analysis to compare early surgical intervention with conservative therapy in patients with infective endocarditis. Methods PubMed, Cochrane, EMBASE, CINAHL and Google-scholar databases were searched from January 1960 to April 2015. Randomised controlled trials, retrospective cohorts and prospective observational studies comparing outcomes between early surgery at 20 days or less and conservative management for infective endocarditis were analysed. Results A total of 21 studies were included. OR of allcause mortality for early surgery was 0.61 (95% CI 0.50 to 0.74, p

Original languageEnglish (US)
Pages (from-to)950-957
Number of pages8
Issue number12
StatePublished - Jun 15 2016


All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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