Early versus late surgical intervention or medical management for infective endocarditis

A systematic review and meta-analysis

Mahesh Anantha Narayanan, Toufik Mahfood Haddad, Andre C. Kalil, Arun Kanmanthareddy, Rakesh M. Suri, George Mansour, Christopher J. Destache, Janani Baskaran, Aryan N. Mooss, Tammy Wichman, Lee E. Morrow, Renuga Vivekanandan

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective Infective endocarditis is associated with high morbidity and mortality and optimal timing for surgical intervention is unclear. We performed a systematic review and meta-analysis to compare early surgical intervention with conservative therapy in patients with infective endocarditis. Methods PubMed, Cochrane, EMBASE, CINAHL and Google-scholar databases were searched from January 1960 to April 2015. Randomised controlled trials, retrospective cohorts and prospective observational studies comparing outcomes between early surgery at 20 days or less and conservative management for infective endocarditis were analysed. Results A total of 21 studies were included. OR of allcause mortality for early surgery was 0.61 (95% CI 0.50 to 0.74, p

Original languageEnglish
Pages (from-to)950-957
Number of pages8
JournalHeart
Volume102
Issue number12
DOIs
StatePublished - Jun 15 2016

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Endocarditis
Meta-Analysis
Mortality
PubMed
Observational Studies
Randomized Controlled Trials
Databases
Prospective Studies
Morbidity
Conservative Treatment

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Narayanan, M. A., Haddad, T. M., Kalil, A. C., Kanmanthareddy, A., Suri, R. M., Mansour, G., ... Vivekanandan, R. (2016). Early versus late surgical intervention or medical management for infective endocarditis: A systematic review and meta-analysis. Heart, 102(12), 950-957. https://doi.org/10.1136/heartjnl-2015-308589

Early versus late surgical intervention or medical management for infective endocarditis : A systematic review and meta-analysis. / Narayanan, Mahesh Anantha; Haddad, Toufik Mahfood; Kalil, Andre C.; Kanmanthareddy, Arun; Suri, Rakesh M.; Mansour, George; Destache, Christopher J.; Baskaran, Janani; Mooss, Aryan N.; Wichman, Tammy; Morrow, Lee E.; Vivekanandan, Renuga.

In: Heart, Vol. 102, No. 12, 15.06.2016, p. 950-957.

Research output: Contribution to journalArticle

Narayanan, MA, Haddad, TM, Kalil, AC, Kanmanthareddy, A, Suri, RM, Mansour, G, Destache, CJ, Baskaran, J, Mooss, AN, Wichman, T, Morrow, LE & Vivekanandan, R 2016, 'Early versus late surgical intervention or medical management for infective endocarditis: A systematic review and meta-analysis', Heart, vol. 102, no. 12, pp. 950-957. https://doi.org/10.1136/heartjnl-2015-308589
Narayanan, Mahesh Anantha ; Haddad, Toufik Mahfood ; Kalil, Andre C. ; Kanmanthareddy, Arun ; Suri, Rakesh M. ; Mansour, George ; Destache, Christopher J. ; Baskaran, Janani ; Mooss, Aryan N. ; Wichman, Tammy ; Morrow, Lee E. ; Vivekanandan, Renuga. / Early versus late surgical intervention or medical management for infective endocarditis : A systematic review and meta-analysis. In: Heart. 2016 ; Vol. 102, No. 12. pp. 950-957.
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