Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor

Kenneth L. Kramer; H. Joseph Yost

doi:10.1016/S1534-5807(01)00107-1

Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor

Kenneth L. Kramer, H. Joseph Yost

Research output: Contribution to journal › Article

106 Scopus citations

Abstract

Heparan sulfate proteoglycans expressed on the Xenopus animal cap ectoderm have been implicated in transmitting left-right information to heart and gut primordia. We report here that syndecan-2 functions in the ectoderm to mediate cardiac and visceral situs, upstream of known asymmetrically expressed genes but independently of its ability to mediate fibronectin fibrillogenesis. Left-right development is dependent on a distinct subset of glycosaminoglycan attachment sites on syndecan-2. A novel in vivo approach with enterokinase demonstrates that syndecan-2 functions in left-right patterning during early gastrulation. We describe a cell-nonautonomous role for ectodermal syndecan-2 in transmitting left-right information to migrating mesoderm. The results further suggest that this function may be related to the transduction of Vg1-related signals.

Original language	English (US)
Pages (from-to)	115-124
Number of pages	10
Journal	Developmental Cell
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/S1534-5807(01)00107-1
State	Published - Jan 1 2002
Externally published	Yes

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All Science Journal Classification (ASJC) codes

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

Cite this

Kramer, K. L., & Yost, H. J. (2002). Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor. Developmental Cell, 2(1), 115-124. https://doi.org/10.1016/S1534-5807(01)00107-1

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10.1016/S1534-5807(01)00107-1