Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor

Ken Kramer, H. Joseph Yost

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Heparan sulfate proteoglycans expressed on the Xenopus animal cap ectoderm have been implicated in transmitting left-right information to heart and gut primordia. We report here that syndecan-2 functions in the ectoderm to mediate cardiac and visceral situs, upstream of known asymmetrically expressed genes but independently of its ability to mediate fibronectin fibrillogenesis. Left-right development is dependent on a distinct subset of glycosaminoglycan attachment sites on syndecan-2. A novel in vivo approach with enterokinase demonstrates that syndecan-2 functions in left-right patterning during early gastrulation. We describe a cell-nonautonomous role for ectodermal syndecan-2 in transmitting left-right information to migrating mesoderm. The results further suggest that this function may be related to the transduction of Vg1-related signals.

Original languageEnglish
Pages (from-to)115-124
Number of pages10
JournalDevelopmental Cell
Volume2
Issue number1
DOIs
StatePublished - 2002
Externally publishedYes

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Syndecan-2
Mesoderm
Ectoderm
Enteropeptidase
Heparan Sulfate Proteoglycans
Gastrulation
Xenopus
Glycosaminoglycans
Fibronectins
Animals
Genes

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Cite this

Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor. / Kramer, Ken; Yost, H. Joseph.

In: Developmental Cell, Vol. 2, No. 1, 2002, p. 115-124.

Research output: Contribution to journalArticle

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