Effect of β adrenergic blockade, pertussis vaccine and Freund's adjuvant on reaginic antibody response in mice

H. Nakazawa, J. Hobday, R. Townley, E. Chaperon

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

IgE synthesis has been reported to be inhibited by theophylline and dibutyryl cyclic adenosine monophosphate and increased by pertussis vaccine. This study was done to determine if chronic β-adrenergic blockade affects IgE antibody production. 72 C57BL/10J mice were sensitized with egg albumin (EA, 125 μg). Groups included: (1) EA alone; (2) EA + complete Freund's adjuvant (FA); (3) EA + B. pertussis (8 x 10 9 organisms); (4) EA + propranolol (0.5 mg/kg) 3 times/day; (5) EA + FA + propranolol; (6) saline alone. Booster was given on day 49. Group 1, given EA alone, failed to develop any passive cutaneous anaphylaxis (PCA) antibodies even after booster, whereas the 72-hour PCA titers ranged from 1/64 to 1/256 for groups treated with propranolol and propranolol + FA, respectively. The results suggest that chronic β-adrenergic blockade enhances IgE antibody formation.

Original languageEnglish (US)
Pages (from-to)197-205
Number of pages9
JournalInternational Archives of Allergy and Applied Immunology
Volume53
Issue number3
DOIs
StatePublished - Jan 1 1977

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

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