Abstract
IgE synthesis has been reported to be inhibited by theophylline and dibutyryl cyclic adenosine monophosphate and increased by pertussis vaccine. This study was done to determine if chronic β-adrenergic blockade affects IgE antibody production. 72 C57BL/10J mice were sensitized with egg albumin (EA, 125 μg). Groups included: (1) EA alone; (2) EA + complete Freund's adjuvant (FA); (3) EA + B. pertussis (8 x 10 9 organisms); (4) EA + propranolol (0.5 mg/kg) 3 times/day; (5) EA + FA + propranolol; (6) saline alone. Booster was given on day 49. Group 1, given EA alone, failed to develop any passive cutaneous anaphylaxis (PCA) antibodies even after booster, whereas the 72-hour PCA titers ranged from 1/64 to 1/256 for groups treated with propranolol and propranolol + FA, respectively. The results suggest that chronic β-adrenergic blockade enhances IgE antibody formation.
| Original language | English |
|---|---|
| Pages (from-to) | 197-205 |
| Number of pages | 9 |
| Journal | International Archives of Allergy and Applied Immunology |
| Volume | 53 |
| Issue number | 3 |
| State | Published - 1977 |
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All Science Journal Classification (ASJC) codes
- Immunology and Allergy
Cite this
Effect of β adrenergic blockade, pertussis vaccine and Freund's adjuvant on reaginic antibody response in mice. / Nakazawa, H.; Hobday, J.; Townley, R.; Chaperon, E.
In: International Archives of Allergy and Applied Immunology, Vol. 53, No. 3, 1977, p. 197-205.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effect of β adrenergic blockade, pertussis vaccine and Freund's adjuvant on reaginic antibody response in mice
AU - Nakazawa, H.
AU - Hobday, J.
AU - Townley, R.
AU - Chaperon, E.
PY - 1977
Y1 - 1977
N2 - IgE synthesis has been reported to be inhibited by theophylline and dibutyryl cyclic adenosine monophosphate and increased by pertussis vaccine. This study was done to determine if chronic β-adrenergic blockade affects IgE antibody production. 72 C57BL/10J mice were sensitized with egg albumin (EA, 125 μg). Groups included: (1) EA alone; (2) EA + complete Freund's adjuvant (FA); (3) EA + B. pertussis (8 x 10 9 organisms); (4) EA + propranolol (0.5 mg/kg) 3 times/day; (5) EA + FA + propranolol; (6) saline alone. Booster was given on day 49. Group 1, given EA alone, failed to develop any passive cutaneous anaphylaxis (PCA) antibodies even after booster, whereas the 72-hour PCA titers ranged from 1/64 to 1/256 for groups treated with propranolol and propranolol + FA, respectively. The results suggest that chronic β-adrenergic blockade enhances IgE antibody formation.
AB - IgE synthesis has been reported to be inhibited by theophylline and dibutyryl cyclic adenosine monophosphate and increased by pertussis vaccine. This study was done to determine if chronic β-adrenergic blockade affects IgE antibody production. 72 C57BL/10J mice were sensitized with egg albumin (EA, 125 μg). Groups included: (1) EA alone; (2) EA + complete Freund's adjuvant (FA); (3) EA + B. pertussis (8 x 10 9 organisms); (4) EA + propranolol (0.5 mg/kg) 3 times/day; (5) EA + FA + propranolol; (6) saline alone. Booster was given on day 49. Group 1, given EA alone, failed to develop any passive cutaneous anaphylaxis (PCA) antibodies even after booster, whereas the 72-hour PCA titers ranged from 1/64 to 1/256 for groups treated with propranolol and propranolol + FA, respectively. The results suggest that chronic β-adrenergic blockade enhances IgE antibody formation.
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M3 - Article
VL - 53
SP - 197
EP - 205
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 3
ER -