Effect of β adrenergic blockade, pertussis vaccine and Freund's adjuvant on reaginic antibody response in mice

H. Nakazawa; J. Hobday; R. Townley; E. Chaperon

doi:10.1159/000231753

Effect of β adrenergic blockade, pertussis vaccine and Freund's adjuvant on reaginic antibody response in mice

H. Nakazawa, J. Hobday, R. Townley, E. Chaperon

Department of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

IgE synthesis has been reported to be inhibited by theophylline and dibutyryl cyclic adenosine monophosphate and increased by pertussis vaccine. This study was done to determine if chronic β-adrenergic blockade affects IgE antibody production. 72 C57BL/10J mice were sensitized with egg albumin (EA, 125 μg). Groups included: (1) EA alone; (2) EA + complete Freund's adjuvant (FA); (3) EA + B. pertussis (8 x 10 ⁹ organisms); (4) EA + propranolol (0.5 mg/kg) 3 times/day; (5) EA + FA + propranolol; (6) saline alone. Booster was given on day 49. Group 1, given EA alone, failed to develop any passive cutaneous anaphylaxis (PCA) antibodies even after booster, whereas the 72-hour PCA titers ranged from 1/64 to 1/256 for groups treated with propranolol and propranolol + FA, respectively. The results suggest that chronic β-adrenergic blockade enhances IgE antibody formation.

Original language	English (US)
Pages (from-to)	197-205
Number of pages	9
Journal	International Archives of Allergy and Applied Immunology
Volume	53
Issue number	3
DOIs	https://doi.org/10.1159/000231753
State	Published - 1977

All Science Journal Classification (ASJC) codes

Immunology and Allergy

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@article{5728ebdd0bc140838f1b2198e63d6680,

title = "Effect of β adrenergic blockade, pertussis vaccine and Freund's adjuvant on reaginic antibody response in mice",

abstract = "IgE synthesis has been reported to be inhibited by theophylline and dibutyryl cyclic adenosine monophosphate and increased by pertussis vaccine. This study was done to determine if chronic β-adrenergic blockade affects IgE antibody production. 72 C57BL/10J mice were sensitized with egg albumin (EA, 125 μg). Groups included: (1) EA alone; (2) EA + complete Freund's adjuvant (FA); (3) EA + B. pertussis (8 x 10 9 organisms); (4) EA + propranolol (0.5 mg/kg) 3 times/day; (5) EA + FA + propranolol; (6) saline alone. Booster was given on day 49. Group 1, given EA alone, failed to develop any passive cutaneous anaphylaxis (PCA) antibodies even after booster, whereas the 72-hour PCA titers ranged from 1/64 to 1/256 for groups treated with propranolol and propranolol + FA, respectively. The results suggest that chronic β-adrenergic blockade enhances IgE antibody formation.",

author = "H. Nakazawa and J. Hobday and R. Townley and E. Chaperon",

year = "1977",

doi = "10.1159/000231753",

language = "English (US)",

volume = "53",

pages = "197--205",

journal = "International Archives of Allergy and Immunology",

issn = "1018-2438",

publisher = "S. Karger AG",

number = "3",

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T1 - Effect of β adrenergic blockade, pertussis vaccine and Freund's adjuvant on reaginic antibody response in mice

AU - Nakazawa, H.

AU - Hobday, J.

AU - Townley, R.

AU - Chaperon, E.

PY - 1977

Y1 - 1977

N2 - IgE synthesis has been reported to be inhibited by theophylline and dibutyryl cyclic adenosine monophosphate and increased by pertussis vaccine. This study was done to determine if chronic β-adrenergic blockade affects IgE antibody production. 72 C57BL/10J mice were sensitized with egg albumin (EA, 125 μg). Groups included: (1) EA alone; (2) EA + complete Freund's adjuvant (FA); (3) EA + B. pertussis (8 x 10 9 organisms); (4) EA + propranolol (0.5 mg/kg) 3 times/day; (5) EA + FA + propranolol; (6) saline alone. Booster was given on day 49. Group 1, given EA alone, failed to develop any passive cutaneous anaphylaxis (PCA) antibodies even after booster, whereas the 72-hour PCA titers ranged from 1/64 to 1/256 for groups treated with propranolol and propranolol + FA, respectively. The results suggest that chronic β-adrenergic blockade enhances IgE antibody formation.

AB - IgE synthesis has been reported to be inhibited by theophylline and dibutyryl cyclic adenosine monophosphate and increased by pertussis vaccine. This study was done to determine if chronic β-adrenergic blockade affects IgE antibody production. 72 C57BL/10J mice were sensitized with egg albumin (EA, 125 μg). Groups included: (1) EA alone; (2) EA + complete Freund's adjuvant (FA); (3) EA + B. pertussis (8 x 10 9 organisms); (4) EA + propranolol (0.5 mg/kg) 3 times/day; (5) EA + FA + propranolol; (6) saline alone. Booster was given on day 49. Group 1, given EA alone, failed to develop any passive cutaneous anaphylaxis (PCA) antibodies even after booster, whereas the 72-hour PCA titers ranged from 1/64 to 1/256 for groups treated with propranolol and propranolol + FA, respectively. The results suggest that chronic β-adrenergic blockade enhances IgE antibody formation.

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JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

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Effect of β adrenergic blockade, pertussis vaccine and Freund's adjuvant on reaginic antibody response in mice

Abstract

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