Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women: A randomized, placebo-controlled, double-blind pilot study

Joan M. Lappe, Iris Kunz, Igor Bendik, Kevin Prudence, Peter Weber, Robert R. Recker, Robert P. Heaney

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose: Many postmenopausal women desire non-pharmaceutical alternatives to hormone therapy for protection against osteoporosis. Soybean isoflavones, especially genistein, are being studied for this purpose. This study examined the effects of synthetic genistein in combination with other potential bone-protective dietary molecules on bone mineral density (BMD) in early postmenopausal women. Methods: In this 6-month double-blind pilot study, 70 subjects were randomized to receive daily either calcium only or the geniVida™ bone blend (GBB), which consisted of genistein (30 mg/days), vitamin D3 (800 IU/days), vitamin K1 (150 μg/days) and polyunsaturated fatty acids (1 g polyunsaturated fatty acids as ethyl ester: eicosapentaenoic acid/docosahexaenoic acid ratio = ~2/1). Markers of bone resorption and formation and BMD at the femoral neck, lumbar spine, Ward's triangle, trochanter and intertrochanter, total hip and whole body were assessed. Results: Subjects supplemented with the GBB (n = 30) maintained femoral neck BMD, whereas in the placebo group (n = 28), BMD significantly decreased (p = 0.007). There was also a significant difference (p <0.05) in BMD between the groups at Ward's triangle in favor of the GBB group. Bone-specific alkaline phosphatase and N-telopeptide significantly increased in the GBB group in comparison with those in baseline and in the placebo group. The GBB was well tolerated, and there were no significant differences in adverse events between groups. Conclusions: The GBB may help to prevent osteoporosis and reduce fracture risk, at least at the hip, in postmenopausal women. Larger and longer-term clinical trials are warranted.

Original languageEnglish
Pages (from-to)203-215
Number of pages13
JournalEuropean Journal of Nutrition
Volume52
Issue number1
DOIs
StatePublished - Feb 2013

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Vitamin K 1
Genistein
Cholecalciferol
Unsaturated Fatty Acids
Double-Blind Method
Bone Density
Placebos
Bone and Bones
Femur Neck
Osteoporosis
Hip
Isoflavones
Docosahexaenoic Acids
Bone Resorption
Soybeans
Osteogenesis
Femur
Alkaline Phosphatase
Spine
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Effect of a combination of genistein, polyunsaturated fatty acids and vitamins D3 and K1 on bone mineral density in postmenopausal women : A randomized, placebo-controlled, double-blind pilot study. / Lappe, Joan M.; Kunz, Iris; Bendik, Igor; Prudence, Kevin; Weber, Peter; Recker, Robert R.; Heaney, Robert P.

In: European Journal of Nutrition, Vol. 52, No. 1, 02.2013, p. 203-215.

Research output: Contribution to journalArticle

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