Abstract
Adenosine and pertussis vaccine each significantly suppresed the in vitro lymphocyte response to photohemagglutinin (PHA) in both asthmatic and non-asthmatic subjects. On the other hand, pertussis vaccine significantly enhanced the response of the lymphocytes treated with a lower concentration of adenosine both in asthmatic and non-asthmatic subjects. It was also shown that lymphocytes from asthmatic and non-asthmatic subjects responded similarly to the modulating effect of adenosine and/or pertussis vaccine on PHA stimulation. These data give further evidence for the complex interplay of the vaccine with endogenous adenosine.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 142-146 |
| Number of pages | 5 |
| Journal | Annals of allergy |
| Volume | 61 |
| Issue number | 2 |
| State | Published - Jan 1 1988 |
All Science Journal Classification (ASJC) codes
- Immunology and Allergy
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Hiratani, M., McCall, M. K., Chaperon, E. A., & Townley, R. G. (1988). Effect of adenosine and pertussis vaccine on lymphocyte response in vitro to phytohemmaglutinin in asthmatic and non-asthmatic subjects. Annals of allergy, 61(2), 142-146.