Effect of adenosine and pertussis vaccine on lymphocyte response in vitro to phytohemmaglutinin in asthmatic and non-asthmatic subjects

M. Hiratani, M. K. McCall, E. A. Chaperon, R. G. Townley

Research output: Contribution to journalArticle

Abstract

Adenosine and pertussis vaccine each significantly suppresed the in vitro lymphocyte response to photohemagglutinin (PHA) in both asthmatic and non-asthmatic subjects. On the other hand, pertussis vaccine significantly enhanced the response of the lymphocytes treated with a lower concentration of adenosine both in asthmatic and non-asthmatic subjects. It was also shown that lymphocytes from asthmatic and non-asthmatic subjects responded similarly to the modulating effect of adenosine and/or pertussis vaccine on PHA stimulation. These data give further evidence for the complex interplay of the vaccine with endogenous adenosine.

Original languageEnglish (US)
Pages (from-to)142-146
Number of pages5
JournalAnnals of allergy
Volume61
Issue number2
StatePublished - Jan 1 1988

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

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