Effect of adenosine and pertussis vaccine on lymphocyte response in vitro to phytohemmaglutinin in asthmatic and non-asthmatic subjects

M. Hiratani, M. K. McCall, E. A. Chaperon, R. G. Townley

Research output: Contribution to journalArticle

Abstract

Adenosine and pertussis vaccine each significantly suppresed the in vitro lymphocyte response to photohemagglutinin (PHA) in both asthmatic and non-asthmatic subjects. On the other hand, pertussis vaccine significantly enhanced the response of the lymphocytes treated with a lower concentration of adenosine both in asthmatic and non-asthmatic subjects. It was also shown that lymphocytes from asthmatic and non-asthmatic subjects responded similarly to the modulating effect of adenosine and/or pertussis vaccine on PHA stimulation. These data give further evidence for the complex interplay of the vaccine with endogenous adenosine.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalAnnals of Allergy
Volume61
Issue number2
StatePublished - 1988
Externally publishedYes

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Pertussis Vaccine
Adenosine
Lymphocytes
Vaccines
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Effect of adenosine and pertussis vaccine on lymphocyte response in vitro to phytohemmaglutinin in asthmatic and non-asthmatic subjects. / Hiratani, M.; McCall, M. K.; Chaperon, E. A.; Townley, R. G.

In: Annals of Allergy, Vol. 61, No. 2, 1988, p. 142-146.

Research output: Contribution to journalArticle

Hiratani, M. ; McCall, M. K. ; Chaperon, E. A. ; Townley, R. G. / Effect of adenosine and pertussis vaccine on lymphocyte response in vitro to phytohemmaglutinin in asthmatic and non-asthmatic subjects. In: Annals of Allergy. 1988 ; Vol. 61, No. 2. pp. 142-146.
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