Effect of aspirin and ibuprofen on GI permeability during exercise

G. Patrick Lambert, M. Boylan, J. P. Laventure, A. Bull, Stephen J. Lanspa

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

This study was conducted to determine the effects of aspirin or ibuprofen on gastrointestinal permeability when combined with exercise. Eight runners completed three 60 min treadmill runs at 70% V̇O2max. For 24 hours prior to each run, subjects ingested aspirin (2 × 325 mg), ibuprofen (2 x 200 mg), or placebo capsules every 6 hours. Immediately before each run, a solution containing 5g sucrose, 5g lactulose, and 2g rhamnose was ingested. Urine produced during each run, and for 4 h afterwards was collected. Urinary excretion of sucrose is an indicator of gastroduodenal permeability. The excretion ratio of lactulose-to-rhamnose assesses small intestinal permeability. Sucrose excretion (%) was greater (p <0.017) for aspirin (0.37 [0.2-0.97]) compared to placebo (0.09 [0.05-0.30]) or ibuprofen (0.22 [0.1-0.39]) and sucrose excretion for ibuprofen was greater than placebo. The lactulose-to-rhamnose ratio was greater for aspirin (0.09 [0.08-0.30]) than placebo (0.065 [0.04-0.08]) however ibuprofen (0.08 [0.06-0.19]) was not different from aspirin or placebo. These results indicate that with prolonged running, gastroduodenal permeability is increased if aspirin or ibuprofen is used prior to such exercise. Furthermore, aspirin promotes greater gastroduodenal permeability and also increases small intestinal permeability.

Original languageEnglish
Pages (from-to)722-726
Number of pages5
JournalInternational Journal of Sports Medicine
Volume28
Issue number9
DOIs
StatePublished - Sep 2007

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Ibuprofen
Aspirin
Permeability
Lactulose
Rhamnose
Placebos
Sucrose
Capsules
Urine

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Effect of aspirin and ibuprofen on GI permeability during exercise. / Lambert, G. Patrick; Boylan, M.; Laventure, J. P.; Bull, A.; Lanspa, Stephen J.

In: International Journal of Sports Medicine, Vol. 28, No. 9, 09.2007, p. 722-726.

Research output: Contribution to journalArticle

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