Effect of aspirin dose on gastrointestinal permeability

G. Patrick Lambert, A. Schmidt, K. Schwarzkopf, Stephen J. Lanspa

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The primary purpose of this study was to determine the aspirin dose that increases gastrointestinal (GI) permeability. A pilot study was also conducted to determine whether the menstrual cycle affects GI permeability. Both portions of the study involved 4 experimental conditions. For the aspirin portion, 8 subjects ingested 0 mg, 325 mg, 650 mg, or 975 mg of aspirin the night before and the morning of an experiment. For the menstrual cycle pilot study, 5 female subjects with regular menstrual cycles were tested for GI permeability on the same day each week for 4 weeks. GI permeability was assessed by the urinary excretion of ingested probes. Sucrose (5 g) was used to determine gastroduodenal permeability. Lactulose (5 g) and rhamnose (2 g) were used to assess small intestinal permeability via the lactulose-to-rhamnose urinary excretion ratio (L/R). The data indicated that the menstrual cycle had no effect on GI permeability. In contrast, gastroduodenal permeability was significantly (P

Original languageEnglish
Pages (from-to)421-425
Number of pages5
JournalInternational Journal of Sports Medicine
Volume33
Issue number6
DOIs
StatePublished - 2012

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Aspirin
Permeability
Menstrual Cycle
Lactulose
Rhamnose
Sucrose

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

Cite this

Effect of aspirin dose on gastrointestinal permeability. / Lambert, G. Patrick; Schmidt, A.; Schwarzkopf, K.; Lanspa, Stephen J.

In: International Journal of Sports Medicine, Vol. 33, No. 6, 2012, p. 421-425.

Research output: Contribution to journalArticle

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