Abstract
OBJECTIVES: The purpose of this study was to evaluate the effect of calcium and vitamin D2 supplementation on bone mineral density (BMD) in children with inflammatory bowel disease (IBD). PATIENTS AND METHODS: This was an open-label, prospective study conducted over a 12-month period. Seventy-two patients were divided into 2 groups based on lumbar spine areal BMD (L2-4 aBMD). Patients with an L2-4 aBMD z score of -1 or higher were assigned to the control group (n = 33; mean age, 11.0 ± 3.5 years; 20 boys). Patients with an L2-4 aBMD of less than -1 (n = 39; mean age 11.8 ± 2.5 years; 25 boys) were allocated to the intervention group and received 1000 mg of supplemental elemental calcium daily for 12 months (n = 19) or supplemental calcium for 12 months and 50,000 IU of vitamin D2 monthly for 6 months (n = 20). RESULTS: The 2 groups differed in L2-4 aBMD z scores (intervention, -1.9 ± 0.6; control, -0.2 ± 0.6; P <0.001) and volumetric L2-4 BMD (vBMD; intervention, 0.29 ± 0.04; control, 0.33 ± 0.06; P <0.001). After 1 year of therapy, the control and intervention groups had similar changes in height z scores, L2-4 aBMD, L2-4 vBMD (z score change, L2-4 aBMD: control 0.2 ± 0.6 [n = 21], intervention 0.4 ± 0.6; P = 0.4 [n = 26]; z score change, L2-4 vBMD: control 0.1 ± 0.4, intervention 0.2 ± 0.6; P = 0.74). The changes in these parameters were similar between patients who had received calcium only or calcium plus vitamin D. CONCLUSIONS: These results suggest that, in children with IBD, supplementation of calcium and vitamin D does not accelerate accrual in L2-4 BMD.
| Original language | English |
|---|---|
| Pages (from-to) | 538-545 |
| Number of pages | 8 |
| Journal | Journal of Pediatric Gastroenterology and Nutrition |
| Volume | 45 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 2007 |
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All Science Journal Classification (ASJC) codes
- Gastroenterology
- Histology
- Medicine (miscellaneous)
- Food Science
- Pediatrics, Perinatology, and Child Health
Cite this
Effect of calcium and vitamin D supplementation on bone mineral density in children with inflammatory bowel disease. / Benchimol, Eric I.; Ward, Leanne M.; Gallagher, John Christopher G.; Rauch, Frank; Barrowman, Nick; Warren, Jaime; Beedle, Susan; Mack, David R.
In: Journal of Pediatric Gastroenterology and Nutrition, Vol. 45, No. 5, 11.2007, p. 538-545.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Effect of calcium and vitamin D supplementation on bone mineral density in children with inflammatory bowel disease
AU - Benchimol, Eric I.
AU - Ward, Leanne M.
AU - Gallagher, John Christopher G.
AU - Rauch, Frank
AU - Barrowman, Nick
AU - Warren, Jaime
AU - Beedle, Susan
AU - Mack, David R.
PY - 2007/11
Y1 - 2007/11
N2 - OBJECTIVES: The purpose of this study was to evaluate the effect of calcium and vitamin D2 supplementation on bone mineral density (BMD) in children with inflammatory bowel disease (IBD). PATIENTS AND METHODS: This was an open-label, prospective study conducted over a 12-month period. Seventy-two patients were divided into 2 groups based on lumbar spine areal BMD (L2-4 aBMD). Patients with an L2-4 aBMD z score of -1 or higher were assigned to the control group (n = 33; mean age, 11.0 ± 3.5 years; 20 boys). Patients with an L2-4 aBMD of less than -1 (n = 39; mean age 11.8 ± 2.5 years; 25 boys) were allocated to the intervention group and received 1000 mg of supplemental elemental calcium daily for 12 months (n = 19) or supplemental calcium for 12 months and 50,000 IU of vitamin D2 monthly for 6 months (n = 20). RESULTS: The 2 groups differed in L2-4 aBMD z scores (intervention, -1.9 ± 0.6; control, -0.2 ± 0.6; P <0.001) and volumetric L2-4 BMD (vBMD; intervention, 0.29 ± 0.04; control, 0.33 ± 0.06; P <0.001). After 1 year of therapy, the control and intervention groups had similar changes in height z scores, L2-4 aBMD, L2-4 vBMD (z score change, L2-4 aBMD: control 0.2 ± 0.6 [n = 21], intervention 0.4 ± 0.6; P = 0.4 [n = 26]; z score change, L2-4 vBMD: control 0.1 ± 0.4, intervention 0.2 ± 0.6; P = 0.74). The changes in these parameters were similar between patients who had received calcium only or calcium plus vitamin D. CONCLUSIONS: These results suggest that, in children with IBD, supplementation of calcium and vitamin D does not accelerate accrual in L2-4 BMD.
AB - OBJECTIVES: The purpose of this study was to evaluate the effect of calcium and vitamin D2 supplementation on bone mineral density (BMD) in children with inflammatory bowel disease (IBD). PATIENTS AND METHODS: This was an open-label, prospective study conducted over a 12-month period. Seventy-two patients were divided into 2 groups based on lumbar spine areal BMD (L2-4 aBMD). Patients with an L2-4 aBMD z score of -1 or higher were assigned to the control group (n = 33; mean age, 11.0 ± 3.5 years; 20 boys). Patients with an L2-4 aBMD of less than -1 (n = 39; mean age 11.8 ± 2.5 years; 25 boys) were allocated to the intervention group and received 1000 mg of supplemental elemental calcium daily for 12 months (n = 19) or supplemental calcium for 12 months and 50,000 IU of vitamin D2 monthly for 6 months (n = 20). RESULTS: The 2 groups differed in L2-4 aBMD z scores (intervention, -1.9 ± 0.6; control, -0.2 ± 0.6; P <0.001) and volumetric L2-4 BMD (vBMD; intervention, 0.29 ± 0.04; control, 0.33 ± 0.06; P <0.001). After 1 year of therapy, the control and intervention groups had similar changes in height z scores, L2-4 aBMD, L2-4 vBMD (z score change, L2-4 aBMD: control 0.2 ± 0.6 [n = 21], intervention 0.4 ± 0.6; P = 0.4 [n = 26]; z score change, L2-4 vBMD: control 0.1 ± 0.4, intervention 0.2 ± 0.6; P = 0.74). The changes in these parameters were similar between patients who had received calcium only or calcium plus vitamin D. CONCLUSIONS: These results suggest that, in children with IBD, supplementation of calcium and vitamin D does not accelerate accrual in L2-4 BMD.
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U2 - 10.1097/MPG.0b013e3180dca0cc
DO - 10.1097/MPG.0b013e3180dca0cc
M3 - Article
VL - 45
SP - 538
EP - 545
JO - Journal of Pediatric Gastroenterology and Nutrition
JF - Journal of Pediatric Gastroenterology and Nutrition
SN - 0277-2116
IS - 5
ER -